Defining uremic arterial functional abnormalities in patients recently started on haemodialysis: combined in vivo and ex vivo assessment

Endothelial dysfunction is a key initiating event in vascular disease in chronic kidney disease (CKD) patients and haemodialysis (HD) patients exhibit significant vascular abnormalities. To understand this further, we examined how ex vivo intrinsic function in isolated arteries correlates with in vi...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e113462-e113462
Hauptverfasser:	Abushufa, Adil M, Eldehni, Mohamed T, Odudu, Aghogho, Evans, Philip D, O'Sullivan, Saoirse E, McIntyre, Chris W
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Abnormalities Acetylcholine Acetylcholine - pharmacology Aged Angiotensin Angiotensin II Angiotensin II - pharmacology Angiotensins Arteries Arteries - physiopathology Biology and Life Sciences Blood pressure Bradykinin Bradykinin - pharmacology Calcification Chronic kidney failure Contractility Endothelin 1 Endothelin-1 - pharmacology Endothelins Endothelium Female Hemodialysis Hospitals Humans Hypertension Ischemia Kidney - physiopathology Kidney diseases Kidney transplantation Male Medicine Medicine and Health Sciences Middle Aged Mortality Muscle Contraction - drug effects Muscle Relaxation - drug effects Myography Nitric oxide Nitroprusside - pharmacology Norepinephrine - pharmacology Patients Peritoneal dialysis Pituitary hormones Potassium Pulse Wave Analysis Renal Dialysis Rodents Sodium Sodium nitroprusside Thromboxane A2 Transplants & implants Uremia - physiopathology Vascular diseases Vasoconstrictor Agents - pharmacology Vasopressin Vasopressins - pharmacology Veins & arteries Wave velocity
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Zusammenfassung:	Endothelial dysfunction is a key initiating event in vascular disease in chronic kidney disease (CKD) patients and haemodialysis (HD) patients exhibit significant vascular abnormalities. To understand this further, we examined how ex vivo intrinsic function in isolated arteries correlates with in vivo assessments of cardiovascular status in HD patients. Abdominal fat biopsies were obtained from 11 HD patients and 26 non-uremic controls. Subcutaneous arteries were dissected and mounted on a wire myograph, and cumulative concentration-response curves to noradrenalin, endothelin-1, a thromboxane A2 agonist (U46619), angiotensin II, vasopressin, bradykinin (BK), acetylcholine (ACh) and sodium nitroprusside (SNP) were constructed. Pulse wave velocity and blood pressure were measured in HD patients. Enhanced (P600 µm. The potency (pEC50) of U46619 (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0113462