Leukocyte telomere length-related rs621559 and rs398652 genetic variants influence risk of HBV-related hepatocellular carcinoma

Recent genome-wide association studies (GWAS) have identified eleven leukocyte telomere length (LTL)-related single nucleotide polymorphisms (SNPs). Since LTL has been associated with risk of many malignancies, LTL-related SNPs may contribute to cancer susceptibility. To test this hypothesis in hepa...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11), p.e110863-e110863
Hauptverfasser:	Pan, Wenting, Cheng, Guangxia, Xing, Huaixin, Shi, Juan, Lu, Chao, Wei, Jinyu, Li, Lichao, Zhou, Changchun, Yuan, Qipeng, Zhou, Liqing, Yang, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Alleles Biomedical materials Carcinoma, Hepatocellular - etiology Carriers Case-Control Studies Cell division Chromosomes Engineering Epidemiology Esophagus Female Gene Frequency Genetic diversity Genetic research Genetic variance Genetic Variation Genome-wide association studies Genome-Wide Association Study Genomes Genomics Genotype Genotypes Health aspects Hepatitis Hepatitis B Hepatitis B - complications Hepatitis B - genetics Hepatitis B virus Hepatocellular carcinoma Humans Laboratories Leukocytes Life sciences Liver cancer Liver Neoplasms - etiology Male Medicine and Health Sciences Middle Aged Oxidative stress Polymorphism, Single Nucleotide Population (statistical) Risk Risk Factors Single nucleotide polymorphisms Single-nucleotide polymorphism Squamous cell carcinoma Telomerase Telomere - genetics Viruses
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Zusammenfassung:	Recent genome-wide association studies (GWAS) have identified eleven leukocyte telomere length (LTL)-related single nucleotide polymorphisms (SNPs). Since LTL has been associated with risk of many malignancies, LTL-related SNPs may contribute to cancer susceptibility. To test this hypothesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we genotyped these eleven LTL-related SNPs in a case-control set including 1186 HBV-related HCC cases, 508 chronic HBV carriers and 1308 healthy controls at the discovery stage. The associations of HCC risk with these SNPs were further confirmed in an independent case-control set. We found that 1p34.2 rs621559 and 14q21 rs398652 were significantly associated with HBV-related HCC risk (both P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0110863