Population snapshot of Streptococcus pneumoniae causing invasive disease in South Africa prior to introduction of pneumococcal conjugate vaccines

We determined the sequence types of isolates that caused invasive pneumococcal disease (IPD) prior to routine use of pneumococcal conjugate vaccines (PCV) in South Africa. PCV-13 serotypes and 6C isolates collected in 2007 (1 461/2 437, 60%) from patients of all ages as part of on-going, national, l...

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Veröffentlicht in:	PloS one 2014-09, Vol.9 (9), p.e107666
Hauptverfasser:	Ndlangisa, Kedibone M, du Plessis, Mignon, Wolter, Nicole, de Gouveia, Linda, Klugman, Keith P, von Gottberg, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults Anti-Bacterial Agents - pharmacology Antibiotics Base Sequence Biology and Life Sciences Child Child, Preschool Children DNA, Bacterial - analysis DNA, Bacterial - genetics Female Genotypes Humans Immunization Laboratories Male Medicine and Health Sciences Microbial Sensitivity Tests Multilocus Sequence Typing Penicillin Penicillins Pneumococcal Infections - drug therapy Pneumococcal Infections - epidemiology Pneumococcal Vaccines - immunology Pneumococcal Vaccines - therapeutic use Pneumonia Sequence Analysis, DNA Serotypes Serotyping South Africa - epidemiology Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - genetics Streptococcus pneumoniae - isolation & purification Vaccines Vaccines, Conjugate - immunology Vaccines, Conjugate - therapeutic use Young Adult
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Zusammenfassung:	We determined the sequence types of isolates that caused invasive pneumococcal disease (IPD) prior to routine use of pneumococcal conjugate vaccines (PCV) in South Africa. PCV-13 serotypes and 6C isolates collected in 2007 (1 461/2 437, 60%) from patients of all ages as part of on-going, national, laboratory-based surveillance for IPD, were selected for genetic characterization. In addition, all 134 non-PCV isolates from children
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0107666