Effects of chitosan on intestinal inflammation in weaned pigs challenged by enterotoxigenic Escherichia coli

The aim of this study was to investigate whether supplementation with chitosan (COS) could reduce diarrhea and to explore how COS alleviates intestinal inflammation in weaned pigs. Thirty pigs (Duroc×Landrace×Yorkshire, initial BW of 5.65±0.27) weaned at age 21 d were challenged with enterotoxigenic...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e104192
Hauptverfasser:	Xiao, Dingfu, Wang, Yongfei, Liu, Gang, He, Jianhua, Qiu, Wei, Hu, Xionggui, Feng, Zemeng, Ran, Maoliang, Nyachoti, Charles M, Kim, Sung Woo, Tang, Zhiru, Yin, Yulong
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Analysis Animal sciences Animals Antibiotics B cells Bacteria Biology and Life Sciences Chitosan Chitosan - administration & dosage Chlortetracycline Corn Cytokines Diarrhea Diarrhea - drug therapy Diarrhea - veterinary Diet Dietary supplements Drug resistance E coli Enterotoxigenic Escherichia coli - drug effects Enterotoxigenic Escherichia coli - pathogenicity Escherichia coli Feces Feed additives Feeds Food additives Gene expression Gene Expression - drug effects Immune response Immune response (cell-mediated) Immune system Immunity, Cellular - drug effects Inflammation Inflammation - drug therapy Inflammation - microbiology Inflammation - veterinary Inflammatory bowel disease Interleukin 6 Intestine Intestines - drug effects Intestines - microbiology Intestines - pathology Laboratories Leukocyte L1 Antigen Complex Molecular weight Morphology Mucosa R&D Research & development Research and Analysis Methods RNA Rodents Soybeans Swine TLR4 protein Toll-Like Receptor 4 - biosynthesis Toll-like receptors Tumor Necrosis Factor-alpha - biosynthesis Tumor necrosis factor-α Weaning Zoology
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Beschreibung
Zusammenfassung:	The aim of this study was to investigate whether supplementation with chitosan (COS) could reduce diarrhea and to explore how COS alleviates intestinal inflammation in weaned pigs. Thirty pigs (Duroc×Landrace×Yorkshire, initial BW of 5.65±0.27) weaned at age 21 d were challenged with enterotoxigenic Escherichia coli during a preliminary trial period, and then divided into three treatment groups. Pigs in individual pens were fed a corn-soybean meal diet, that contained either 0 (control), 50 mg/kg chlortetracycline, or 300 mg/kg COS for 21 days. The post-weaning diarrhea frequency, calprotectin levels and TLR4 protein expression were decreased (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0104192