Effect of pregnancy on anti-HEV antibody titres, plasma cytokines and the corresponding gene expression levels in the PBMCs of patients presenting with self-recovering clinical and subclinical hepatitis E

High mortality in pregnant women (PR) is a characteristic of hepatitis E in developing countries. To understand the pathogenesis of HEV infection in self-limiting disease during pregnancy, we compared clinical (PR-patients) and subclinical-HEV-infections in pregnant women in the first (SC-PR-1) and...

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Veröffentlicht in:	PloS one 2014-08, Vol.9 (8), p.e103257-e103257
Hauptverfasser:	Ramdasi, Ashwini Y, Arya, Ravi P, Arankalle, Vidya A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies Bilirubin Biology and Life Sciences Blood Chemical Analysis Case-Control Studies CCL3 protein Cluster Analysis Comparative analysis CXCL10 protein Cytokines Cytokines - blood Cytokines - genetics Developing countries Development and progression Disease Disease control Epidemics Female Gene Expression Gene Expression Profiling Genes Health aspects Hepatitis Hepatitis Antibodies - blood Hepatitis Antibodies - immunology Hepatitis E Hepatitis E - blood Hepatitis E - etiology Hepatitis E - genetics Hepatitis E virus - immunology Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Humans Immune response Immune system Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M Immunoglobulin M - blood Immunoglobulin M - immunology Immunoglobulins Infection Infections Inflammation Inflammatory response Influenza Interferon Interleukin 1 Interleukin 10 Interleukin 2 Interleukin 6 Interleukin 7 LDCs Leukocytes, Mononuclear - metabolism Liver Function Tests Lymphocytes T Male Medicine and Health Sciences Monocyte chemoattractant protein 1 Mortality Pathogenesis Patients Plasma Pregnancy Pregnancy Complications, Infectious Pregnant women Tumor necrosis factor Viral infections Virology Womens health Young Adult γ-Interferon
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Zusammenfassung:	High mortality in pregnant women (PR) is a characteristic of hepatitis E in developing countries. To understand the pathogenesis of HEV infection in self-limiting disease during pregnancy, we compared clinical (PR-patients) and subclinical-HEV-infections in pregnant women in the first (SC-PR-1) and later (2nd and 3rd, SC-PR-2+3) trimesters with the respective healthy controls and acute non-PR patients. The SC-PR-2+3 exhibited lower ALT, bilirubin levels, anti-HEV-IgM/IgG titres than the acute-PR/non-PR-patients (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0103257