Temporal profile and mechanisms of the prompt sympathoexcitation following coronary ligation in Wistar rats

Our aim was to assess the timing and mechanisms of the sympathoexcitation that occurs immediately after coronary ligation. We recorded thoracic sympathetic (tSNA) and phrenic activities, heart rate (HR) and perfusion pressure in Wistar rats subjected to either ligation of the left anterior descendin...

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Veröffentlicht in:	PloS one 2014-07, Vol.9 (7), p.e101886-e101886
Hauptverfasser:	Passamani, Luciana Mesquita, Abdala, Ana Paula, Moraes, Davi José de Almeida, Sampaio, Karla Nívea, Mill, José Geraldo, Paton, Julian Francis Richmond
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Angiotensins Animals Atenolol Augmentation Baroreceptors Baroreflex Biology and Life Sciences Blood pressure Brain stem Cardiac arrhythmia Cerebrovascular Circulation - drug effects Chemoreception (internal) Coronary artery Coronary vessels Coronary Vessels - injuries Coronary Vessels - physiopathology Health sciences Heart attacks Heart diseases Heart failure Heart rate Heart Rate - drug effects Heart Rate - physiology Hypertension Kinases Losartan - pharmacology Male Medical research Medicine and Health Sciences Perfusion Pharmacology Phenylephrine Phrenic Nerve - physiopathology Physiology Rats Rats, Wistar Receptor, Angiotensin, Type 1 Reflexes Rodents Sympathetic nervous system Sympathetic Nervous System - physiopathology Thorax Vagus nerve
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Zusammenfassung:	Our aim was to assess the timing and mechanisms of the sympathoexcitation that occurs immediately after coronary ligation. We recorded thoracic sympathetic (tSNA) and phrenic activities, heart rate (HR) and perfusion pressure in Wistar rats subjected to either ligation of the left anterior descending coronary artery (LAD) or Sham operated in the working heart-brainstem preparation. Thirty minutes after LAD ligation, tSNA had increased (basal: 2.5±0.2 µV, 30 min: 3.5±0.3 µV), being even higher at 60 min (5.2±0.5 µV, P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0101886