Prognostic value of PLR in various cancers: a meta-analysis
Recently, more and more studies investigated the association of inflammation parameters such as the Platelet Lymphocyte Ratio (PLR) and the prognosis of various cancers. However, the prognostic role of PLR in cancer remains controversial. We conducted a meta-analysis of published studies to evaluate...
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| Veröffentlicht in: | PloS one 2014-06, Vol.9 (6), p.e101119-e101119 |
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| creator | Zhou, Xin Du, Yiping Huang, Zebo Xu, Jun Qiu, Tianzhu Wang, Jian Wang, Tongshan Zhu, Wei Liu, Ping |
| description | Recently, more and more studies investigated the association of inflammation parameters such as the Platelet Lymphocyte Ratio (PLR) and the prognosis of various cancers. However, the prognostic role of PLR in cancer remains controversial.
We conducted a meta-analysis of published studies to evaluate the prognostic value of PLR in various cancers. In order to investigate the association between PLR and overall survival (OS), the hazard ratio (HR) and its 95% confidence interval (CI) were calculated.
A total of 13,964 patients from 26 studies were included in the analysis. The summary results showed that elevated PLR was a negative predictor for OS with HR of 1.60 (95%CI: 1.35-1.90; Pheterogeneity |
| doi_str_mv | 10.1371/journal.pone.0101119 |
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We conducted a meta-analysis of published studies to evaluate the prognostic value of PLR in various cancers. In order to investigate the association between PLR and overall survival (OS), the hazard ratio (HR) and its 95% confidence interval (CI) were calculated.
A total of 13,964 patients from 26 studies were included in the analysis. The summary results showed that elevated PLR was a negative predictor for OS with HR of 1.60 (95%CI: 1.35-1.90; Pheterogeneity <0.001). Subgroup analysis revealed that increased PLR was a negative prognostic marker in patients with gastric cancer (HR = 1.35, 95%CI: 0.80-2.25, Pheterogeneity = 0.011), colorectal cancer (HR = 1.65, 95%CI: 1.33-2.05, Pheterogeneity = 0.995), hepatocellular carcinoma (HR = 3.07, 95% CI: 2.04-4.62, Pheterogeneity = 0.133), ovarian cancer (HR = 1.57, 95%CI: 1.07-2.31, Pheterogeneity = 0.641) and non-small cell lung cancer (NSCLC) (HR = 1.85, 95% CI: 1.42-2.41, Pheterogeneity = 0.451) except for pancreatic cancer (HR = 1.00, 95%CI: 0.92-1.09, Pheterogeneity = 0.388).
The meta-analysis demonstrated that PLR could act as a significant biomarker in the prognosis of various cancers.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0101119</identifier><identifier>PMID: 24968121</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Bioindicators ; Biology and Life Sciences ; Biomarkers ; Blood platelets ; Cancer ; Colorectal cancer ; Colorectal carcinoma ; Confidence intervals ; Ethnicity ; Gastric cancer ; Hepatocellular carcinoma ; Humans ; Inflammation ; Liver cancer ; Lung cancer ; Lung diseases ; Lymphocyte Count ; Lymphocytes ; Medical prognosis ; Medicine and Health Sciences ; Meta-analysis ; Metastasis ; Methods ; Neoplasms - blood ; Neoplasms - mortality ; Neutrophils ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Odds Ratio ; Oncology ; Ovarian cancer ; Ovarian carcinoma ; Pancreatic cancer ; Patients ; Physical Sciences ; Platelet Count ; Prognosis ; Proportional Hazards Models ; Research and Analysis Methods ; Studies ; Systematic review</subject><ispartof>PloS one, 2014-06, Vol.9 (6), p.e101119-e101119</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Zhou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Zhou et al 2014 Zhou et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c809t-7083e6471a8edf6f05b24a75bd2914a3f5c38cb9c39375b49a5a759351196ac83</citedby><cites>FETCH-LOGICAL-c809t-7083e6471a8edf6f05b24a75bd2914a3f5c38cb9c39375b49a5a759351196ac83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072728/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072728/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24968121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Xin</creatorcontrib><creatorcontrib>Du, Yiping</creatorcontrib><creatorcontrib>Huang, Zebo</creatorcontrib><creatorcontrib>Xu, Jun</creatorcontrib><creatorcontrib>Qiu, Tianzhu</creatorcontrib><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Wang, Tongshan</creatorcontrib><creatorcontrib>Zhu, Wei</creatorcontrib><creatorcontrib>Liu, Ping</creatorcontrib><title>Prognostic value of PLR in various cancers: a meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Recently, more and more studies investigated the association of inflammation parameters such as the Platelet Lymphocyte Ratio (PLR) and the prognosis of various cancers. However, the prognostic role of PLR in cancer remains controversial.
We conducted a meta-analysis of published studies to evaluate the prognostic value of PLR in various cancers. In order to investigate the association between PLR and overall survival (OS), the hazard ratio (HR) and its 95% confidence interval (CI) were calculated.
A total of 13,964 patients from 26 studies were included in the analysis. The summary results showed that elevated PLR was a negative predictor for OS with HR of 1.60 (95%CI: 1.35-1.90; Pheterogeneity <0.001). Subgroup analysis revealed that increased PLR was a negative prognostic marker in patients with gastric cancer (HR = 1.35, 95%CI: 0.80-2.25, Pheterogeneity = 0.011), colorectal cancer (HR = 1.65, 95%CI: 1.33-2.05, Pheterogeneity = 0.995), hepatocellular carcinoma (HR = 3.07, 95% CI: 2.04-4.62, Pheterogeneity = 0.133), ovarian cancer (HR = 1.57, 95%CI: 1.07-2.31, Pheterogeneity = 0.641) and non-small cell lung cancer (NSCLC) (HR = 1.85, 95% CI: 1.42-2.41, Pheterogeneity = 0.451) except for pancreatic cancer (HR = 1.00, 95%CI: 0.92-1.09, Pheterogeneity = 0.388).
The meta-analysis demonstrated that PLR could act as a significant biomarker in the prognosis of various cancers.</description><subject>Analysis</subject><subject>Bioindicators</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Blood platelets</subject><subject>Cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Confidence intervals</subject><subject>Ethnicity</subject><subject>Gastric cancer</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Metastasis</subject><subject>Methods</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - mortality</subject><subject>Neutrophils</subject><subject>Non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Odds Ratio</subject><subject>Oncology</subject><subject>Ovarian cancer</subject><subject>Ovarian carcinoma</subject><subject>Pancreatic cancer</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Platelet Count</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Research and Analysis Methods</subject><subject>Studies</subject><subject>Systematic 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Xin</au><au>Du, Yiping</au><au>Huang, Zebo</au><au>Xu, Jun</au><au>Qiu, Tianzhu</au><au>Wang, Jian</au><au>Wang, Tongshan</au><au>Zhu, Wei</au><au>Liu, Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of PLR in various cancers: a meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-06-26</date><risdate>2014</risdate><volume>9</volume><issue>6</issue><spage>e101119</spage><epage>e101119</epage><pages>e101119-e101119</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Recently, more and more studies investigated the association of inflammation parameters such as the Platelet Lymphocyte Ratio (PLR) and the prognosis of various cancers. However, the prognostic role of PLR in cancer remains controversial.
We conducted a meta-analysis of published studies to evaluate the prognostic value of PLR in various cancers. In order to investigate the association between PLR and overall survival (OS), the hazard ratio (HR) and its 95% confidence interval (CI) were calculated.
A total of 13,964 patients from 26 studies were included in the analysis. The summary results showed that elevated PLR was a negative predictor for OS with HR of 1.60 (95%CI: 1.35-1.90; Pheterogeneity <0.001). Subgroup analysis revealed that increased PLR was a negative prognostic marker in patients with gastric cancer (HR = 1.35, 95%CI: 0.80-2.25, Pheterogeneity = 0.011), colorectal cancer (HR = 1.65, 95%CI: 1.33-2.05, Pheterogeneity = 0.995), hepatocellular carcinoma (HR = 3.07, 95% CI: 2.04-4.62, Pheterogeneity = 0.133), ovarian cancer (HR = 1.57, 95%CI: 1.07-2.31, Pheterogeneity = 0.641) and non-small cell lung cancer (NSCLC) (HR = 1.85, 95% CI: 1.42-2.41, Pheterogeneity = 0.451) except for pancreatic cancer (HR = 1.00, 95%CI: 0.92-1.09, Pheterogeneity = 0.388).
The meta-analysis demonstrated that PLR could act as a significant biomarker in the prognosis of various cancers.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24968121</pmid><doi>10.1371/journal.pone.0101119</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Bioindicators Biology and Life Sciences Biomarkers Blood platelets Cancer Colorectal cancer Colorectal carcinoma Confidence intervals Ethnicity Gastric cancer Hepatocellular carcinoma Humans Inflammation Liver cancer Lung cancer Lung diseases Lymphocyte Count Lymphocytes Medical prognosis Medicine and Health Sciences Meta-analysis Metastasis Methods Neoplasms - blood Neoplasms - mortality Neutrophils Non-small cell lung cancer Non-small cell lung carcinoma Odds Ratio Oncology Ovarian cancer Ovarian carcinoma Pancreatic cancer Patients Physical Sciences Platelet Count Prognosis Proportional Hazards Models Research and Analysis Methods Studies Systematic review |
| title | Prognostic value of PLR in various cancers: a meta-analysis |
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