Prognostic value of PLR in various cancers: a meta-analysis

Recently, more and more studies investigated the association of inflammation parameters such as the Platelet Lymphocyte Ratio (PLR) and the prognosis of various cancers. However, the prognostic role of PLR in cancer remains controversial. We conducted a meta-analysis of published studies to evaluate...

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Veröffentlicht in:	PloS one 2014-06, Vol.9 (6), p.e101119-e101119
Hauptverfasser:	Zhou, Xin, Du, Yiping, Huang, Zebo, Xu, Jun, Qiu, Tianzhu, Wang, Jian, Wang, Tongshan, Zhu, Wei, Liu, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Bioindicators Biology and Life Sciences Biomarkers Blood platelets Cancer Colorectal cancer Colorectal carcinoma Confidence intervals Ethnicity Gastric cancer Hepatocellular carcinoma Humans Inflammation Liver cancer Lung cancer Lung diseases Lymphocyte Count Lymphocytes Medical prognosis Medicine and Health Sciences Meta-analysis Metastasis Methods Neoplasms - blood Neoplasms - mortality Neutrophils Non-small cell lung cancer Non-small cell lung carcinoma Odds Ratio Oncology Ovarian cancer Ovarian carcinoma Pancreatic cancer Patients Physical Sciences Platelet Count Prognosis Proportional Hazards Models Research and Analysis Methods Studies Systematic review
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Zusammenfassung:	Recently, more and more studies investigated the association of inflammation parameters such as the Platelet Lymphocyte Ratio (PLR) and the prognosis of various cancers. However, the prognostic role of PLR in cancer remains controversial. We conducted a meta-analysis of published studies to evaluate the prognostic value of PLR in various cancers. In order to investigate the association between PLR and overall survival (OS), the hazard ratio (HR) and its 95% confidence interval (CI) were calculated. A total of 13,964 patients from 26 studies were included in the analysis. The summary results showed that elevated PLR was a negative predictor for OS with HR of 1.60 (95%CI: 1.35-1.90; Pheterogeneity
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0101119