FBI-1 enhances ETS-1 signaling activity and promotes proliferation of human colorectal carcinoma cells

In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e98041-e98041
Hauptverfasser:	Zhu, Min, Li, Mingyang, Zhang, Fan, Feng, Fan, Chen, Weihao, Yang, Yutao, Cui, Jiajun, Zhang, Dong, Linghu, Enqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Active Transport, Cell Nucleus Apoptosis Biology and Life Sciences Breast cancer Carcinoma Cell Line, Tumor Cell Nucleus - metabolism Cell Proliferation Cloning Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - pathology DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism ETS protein Gastroenterology Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genes Humans Immunoglobulins Leukemia Matrix Metalloproteinase 1 - genetics Medical prognosis Medicine and Health Sciences Neoplasm Invasiveness p53 Protein Plasmids Promoter Regions, Genetic - genetics Proteins Proto-Oncogene Protein c-ets-1 - metabolism Regulation Signal Transduction Signaling Transcription factors Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tumor proteins Tumor Suppressor Protein p53 - metabolism
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Zusammenfassung:	In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0098041