Efficacy and safety of vitamin K-antagonists (VKA) for atrial fibrillation in non-dialysis dependent chronic kidney disease

Essential information regarding efficacy and safety of vitamin K-antagonists (VKA) treatment for atrial fibrillation (AF) in non-dialysis dependent chronic kidney disease (CKD) is still lacking in current literature. The aim of our study was to compare the risks of stroke or transient ischemic attac...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e94420
Hauptverfasser:	Kooiman, Judith, van Rein, Nienke, Spaans, Bas, van Beers, Koen A J, Bank, Jonna R, van de Peppel, Wilke R, del Sol, Antonio Iglesias, Cannegieter, Suzanne C, Rabelink, Ton J, Lip, Gregory Y H, Klok, Frederikus A, Huisman, Menno V
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Analysis Antagonists Anticoagulants Anticoagulants - adverse effects Anticoagulants - therapeutic use Atrial fibrillation Atrial Fibrillation - complications Atrial Fibrillation - drug therapy Biology and Life Sciences Bleeding Cardiac arrhythmia Care and treatment Chronic kidney failure Comorbidity Dialysis Effectiveness Epidermal growth factor receptors Female Fibrillation Follow-Up Studies Growth rate Health aspects Health risks Hemodialysis Hemorrhage - chemically induced Hospitals Humans Internal medicine Ischemia Ischemic Attack, Transient - chemically induced Kidney diseases Kidney transplantation Male Medical records Medicine and Health Sciences Middle Aged Mortality Multivariate Analysis Patients Proportional Hazards Models Regression analysis Renal Dialysis Renal function Renal Insufficiency, Chronic - complications Risk Assessment - statistics & numerical data Risk Factors Safety Stroke Stroke - chemically induced Stroke patients Thrombosis Transient ischemic attack Treatment Outcome Vitamin K Vitamin K - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	Essential information regarding efficacy and safety of vitamin K-antagonists (VKA) treatment for atrial fibrillation (AF) in non-dialysis dependent chronic kidney disease (CKD) is still lacking in current literature. The aim of our study was to compare the risks of stroke or transient ischemic attack (TIA) and major bleeds between patients without CKD (eGFR >60 ml/min), and those with moderate (eGFR 30-60 ml/min), or severe non-dialysis dependent CKD (eGFR
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0094420