Mitochondrial DNA variants in obesity

Heritability estimates for body mass index (BMI) variation are high. For mothers and their offspring higher BMI correlations have been described than for fathers. Variation(s) in the exclusively maternally inherited mitochondrial DNA (mtDNA) might contribute to this parental effect. Thirty-two to 40...

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Veröffentlicht in:	PloS one 2014-05, Vol.9 (5), p.e94882
Hauptverfasser:	Knoll, Nadja, Jarick, Ivonne, Volckmar, Anna-Lena, Klingenspor, Martin, Illig, Thomas, Grallert, Harald, Gieger, Christian, Wichmann, Heinz-Erich, Peters, Annette, Wiegand, Susanna, Biebermann, Heike, Fischer-Posovszky, Pamela, Wabitsch, Martin, Völzke, Henry, Nauck, Matthias, Teumer, Alexander, Rosskopf, Dieter, Rimmbach, Christian, Schreiber, Stefan, Jacobs, Gunnar, Lieb, Wolfgang, Franke, Andre, Hebebrand, Johannes, Hinney, Anke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescent obesity Adolescents Adult Adults Aged Alleles Analysis Binding sites Biology and Life Sciences Biometrics Body mass Body mass index Body size Case-Control Studies Child & adolescent psychiatry Childhood obesity Children Children & youth Chromosomes Correlation Deoxyribonucleic acid Diabetes DNA DNA, Mitochondrial - genetics Endocrinology Environmental health Epidemiology Families & family life Female Genes Genome-wide association studies Genome-Wide Association Study Genomes Genomics Haplotypes - genetics Heritability Humans Identification Male Medicine Middle Aged Mitochondrial DNA Molecular biology Mothers Obesity Obesity - genetics Offspring Parenting Pediatrics Phosphorylation Polymorphism, Single Nucleotide Progeny Sequence Analysis, DNA Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Teenagers Variation Young Adult
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Zusammenfassung:	Heritability estimates for body mass index (BMI) variation are high. For mothers and their offspring higher BMI correlations have been described than for fathers. Variation(s) in the exclusively maternally inherited mitochondrial DNA (mtDNA) might contribute to this parental effect. Thirty-two to 40 mtDNA single nucleotide polymorphisms (SNPs) were available from genome-wide association study SNP arrays (Affymetrix 6.0). For discovery, we analyzed association in a case-control (CC) sample of 1,158 extremely obese children and adolescents and 435 lean adult controls. For independent confirmation, 7,014 population-based adults were analyzed as CC sample of n = 1,697 obese cases (BMI ≥ 30 kg/m2) and n = 2,373 normal weight and lean controls (BMI
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0094882