Molecular characterization of Cryptosporidium spp. in children from Mexico

Cryptosporidiosis is a parasitic disease caused by Cryptosporidium spp. In immunocompetent individuals, it usually causes an acute and self-limited diarrhea; in infants, infection with Cryptosporidium spp. can cause malnutrition and growth retardation, and declined cognitive ability. In this study,...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e96128-e96128
Hauptverfasser:	Valenzuela, Olivia, González-Díaz, Mariana, Garibay-Escobar, Adriana, Burgara-Estrella, Alexel, Cano, Manuel, Durazo, María, Bernal, Rosa M, Hernandez, Jesús, Xiao, Lihua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biology and Life Sciences Care and treatment Child Child, Preschool Children Cognitive ability Consent Cryptosporidiosis Cryptosporidiosis - parasitology Cryptosporidium Cryptosporidium - classification Cryptosporidium - genetics Cryptosporidium hominis Cryptosporidium parvum Diagnosis Diarrhea Distribution Epidemiology Families & family life Feces - parasitology Female Genes, Protozoan Glycoproteins Glycoproteins - genetics Growth rate Hospitals Humans Infant Infants Infectious diseases Male Malnutrition Medicine and Health Sciences Mexico Molecular Typing Parasites Parasitic diseases Parasitology Protozoan Proteins - genetics Reptiles & amphibians Risk factors Sequence Analysis, DNA
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Zusammenfassung:	Cryptosporidiosis is a parasitic disease caused by Cryptosporidium spp. In immunocompetent individuals, it usually causes an acute and self-limited diarrhea; in infants, infection with Cryptosporidium spp. can cause malnutrition and growth retardation, and declined cognitive ability. In this study, we described for the first time the distribution of C. parvum and C. hominis subtypes in 12 children in Mexico by sequence characterization of the 60-kDa glycoprotein (GP60) gene of Cryptosporidium. Altogether, 7 subtypes belonging to 4 subtype families of C. hominis (Ia, Ib, Id and Ie) and 1 subtype family of C. parvum (IIa) were detected, including IaA14R3, IaA15R3, IbA10G2, IdA17, IeA11G3T3, IIaA15G2R1 and IIaA16G1R1. The frequency of the subtype families and subtypes in the samples analyzed in this study differed from what was observed in other countries.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0096128