Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor

Members of the steroid receptor coactivator (SRC) family are overexpressed in numerous types of cancers. In particular, steroid receptor coactivator 3 (SRC-3) has been recognized as a critical coactivator associated with tumor initiation, progression, recurrence, metastasis, and chemoresistance wher...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e95243
Hauptverfasser:	Yan, Fei, Yu, Yang, Chow, Dar-Chone, Palzkill, Timothy, Madoux, Franck, Hodder, Peter, Chase, Peter, Griffin, Patrick R, O'Malley, Bert W, Lonard, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic agents Antineoplastic agents Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biology and Life Sciences Breast cancer Cancer Cell growth Cell migration Chemoresistance Collagenase 3 Complications and side effects Cytotoxicity Dosage and administration Drug therapy Drugs Estrogens Event-related potentials Gelatinase A Gene expression Genetic aspects HeLa Cells Hepatocytes High-throughput screening Humans Insulin-like growth factors Kinases Liver Medicine and Health Sciences Metastases Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - metabolism Nuclear Receptor Coactivator 1 - metabolism Nuclear Receptor Coactivator 2 - metabolism Nuclear Receptor Coactivator 3 - antagonists & inhibitors Nuclear Receptor Coactivator 3 - metabolism Nuclear receptors p300 Protein p300-CBP Transcription Factors - metabolism Protein-Arginine N-Methyltransferases - metabolism Proteolysis - drug effects Receptors Signal transduction Signal Transduction - drug effects Signaling Src protein Steroid receptor coactivator 1 Transcription factors Trichothecenes - chemistry Trichothecenes - pharmacology Tumors
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