Genetic determinants influencing human serum metabolome among African Americans

Phenotypes proximal to gene action generally reflect larger genetic effect sizes than those that are distant. The human metabolome, a result of multiple cellular and biological processes, are functional intermediate phenotypes proximal to gene action. Here, we present a genome-wide association study...

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Veröffentlicht in:	PLoS genetics 2014-03, Vol.10 (3), p.e1004212-e1004212
Hauptverfasser:	Yu, Bing, Zheng, Yan, Alexander, Danny, Morrison, Alanna C, Coresh, Josef, Boerwinkle, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - blood Acetyltransferases - genetics African Americans African Americans - genetics Alleles Atherosclerosis Atherosclerosis - blood Atherosclerosis - genetics Atherosclerosis - pathology Diabetes Diabetes Mellitus - blood Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Enzymes Gender Gene loci Genealogy Genetic aspects Genetic polymorphisms Genetic research Genome-Wide Association Study Genomes Humans Kidney diseases Medicine Metabolites Metabolome - genetics Older people Phenotype Polymorphism, Single Nucleotide Population genetics Studies Trehalose - blood Trehalose - genetics
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Zusammenfassung:	Phenotypes proximal to gene action generally reflect larger genetic effect sizes than those that are distant. The human metabolome, a result of multiple cellular and biological processes, are functional intermediate phenotypes proximal to gene action. Here, we present a genome-wide association study of 308 untargeted metabolite levels among African Americans from the Atherosclerosis Risk in Communities (ARIC) Study. Nineteen significant common variant-metabolite associations were identified, including 13 novel loci (p
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1004212