Quantitative assessment of the effect of KCNJ11 gene polymorphism on the risk of type 2 diabetes

To clarify the role of potassium inwardly-rectifying-channel, subfamily-J, member 11 (KCNJ11) variation in susceptibility to type 2 diabetes (T2D), we performed a systematic meta-analysis to investigate the association between the KCNJ11 E23K polymorphism (rs5219) and the T2D in different genetic mo...

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Veröffentlicht in:	PloS one 2014-04, Vol.9 (4), p.e93961-e93961
Hauptverfasser:	Qiu, Ling, Na, Risu, Xu, Rong, Wang, Siyang, Sheng, Hongguang, Wu, Wanling, Qu, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Alleles Analysis Asian Continental Ancestry Group - genetics Biology and Life Sciences Body mass Body mass index Care and treatment Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - genetics Diagnosis Endocrinology Epidemics Ethnicity European Continental Ancestry Group - genetics Gene polymorphism Genes Genetic aspects Genetic Association Studies Genetic diversity Genetic polymorphisms Genetic Predisposition to Disease Genetic variance Genotype Geriatrics Health risks Humans Insulin resistance KCNJ11 gene Medicine and Health Sciences Meta-analysis Minority & ethnic groups Pancreatic beta cells Physical Sciences Polymorphism Polymorphism, Single Nucleotide Population Populations Potassium Potassium Channels, Inwardly Rectifying - genetics Regression analysis Research and Analysis Methods Risk factors Statistical analysis Studies Type 2 diabetes
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Zusammenfassung:	To clarify the role of potassium inwardly-rectifying-channel, subfamily-J, member 11 (KCNJ11) variation in susceptibility to type 2 diabetes (T2D), we performed a systematic meta-analysis to investigate the association between the KCNJ11 E23K polymorphism (rs5219) and the T2D in different genetic models. Databases including PubMed, Medline, EMBASE, and ISI Web of Science were searched to identify relevant studies. A total of 48 published studies involving 56,349 T2D cases, 81,800 controls, and 483 family trios were included in this meta-analysis. Overall, the E23K polymorphism was significantly associated with increased T2D risk with per-allele odds ratio (OR) of 1.12 (95% CI: 1.09-1.16; P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0093961