Field evaluation of PIMA point-of-care CD4 testing in Rakai, Uganda

To assess the accuracy of PIMA Point-of-Care (POC) CD4 testing in rural Rakai, Uganda. 903 HIV positive persons attending field clinics provided a venous blood sample assessed on site using PIMA analyzers per manufacturer's specifications. The venous samples were then run on FACSCalibur flow cy...

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Veröffentlicht in:	PloS one 2014-03, Vol.9 (3), p.e88928-e88928
Hauptverfasser:	Galiwango, Ronald M, Lubyayi, Lawrence, Musoke, Richard, Kalibbala, Sarah, Buwembo, Martin, Kasule, Jjingo, Serwadda, David, Gray, Ronald H, Reynolds, Steven J, Chang, Larry W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analyzers Antiretroviral agents Antiretroviral drugs Antiretroviral Therapy, Highly Active Bias Biology Blood CD4 antigen CD4 Lymphocyte Count - instrumentation CD4 Lymphocyte Count - methods Cytometry Flow Cytometry Humans Medicine Point-of-Care Systems Predictive Value of Tests Reference Values Sensitivity Sensitivity and Specificity Uganda
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Beschreibung
Zusammenfassung:	To assess the accuracy of PIMA Point-of-Care (POC) CD4 testing in rural Rakai, Uganda. 903 HIV positive persons attending field clinics provided a venous blood sample assessed on site using PIMA analyzers per manufacturer's specifications. The venous samples were then run on FACSCalibur flow cytometry at a central facility. The Bland-Altman method was used to estimate mean bias and 95% limits of agreement (LOA). Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated for a CD4 threshold of
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0088928