Male-specific association between dopamine receptor D4 gene methylation and schizophrenia

The goal of our study was to investigate whether DRD4 gene DNA methylation played an important role in the susceptibility of Han Chinese SCZ. Using the bisulphite pyrosequencing technology, DNA methylation levels of 6 CpG dinucleotides in DRD4 CpG island were measured among 30 paranoid SCZ patients,...

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Veröffentlicht in:	PloS one 2014-02, Vol.9 (2), p.e89128-e89128
Hauptverfasser:	Cheng, Jia, Wang, Yunliang, Zhou, Kena, Wang, Lingyan, Li, Jinfeng, Zhuang, Qidong, Xu, Xuting, Xu, Leiting, Zhang, Kai, Dai, Dongjun, Zheng, Rongjiong, Li, Guangxue, Zhang, Aiping, Gao, Shugui, Duan, Shiwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Analysis Antipsychotics Behavior disorders Biology Cardiovascular disease Child CpG islands Deoxyribonucleic acid DNA DNA Methylation Dopamine Dopamine D4 receptors Dopamine receptors Drug abuse Epigenetics Event-related potentials Female Females Gender Gene expression Gene regulation Genes Genetic Association Studies Genetic Predisposition to Disease Hospitals Humans Laboratories Linkage Disequilibrium Male Males Medicine Mental disorders Methylation Pathogenesis Patients Phenols (Class of compounds) Promoter Regions, Genetic Psychiatry Psychotropic drugs Receptors, Dopamine D4 - genetics Receptors, Dopamine D4 - metabolism Schizophrenia Schizophrenia - epidemiology Schizophrenia - genetics Sex Factors Young Adult
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Zusammenfassung:	The goal of our study was to investigate whether DRD4 gene DNA methylation played an important role in the susceptibility of Han Chinese SCZ. Using the bisulphite pyrosequencing technology, DNA methylation levels of 6 CpG dinucleotides in DRD4 CpG island were measured among 30 paranoid SCZ patients, 30 undifferentiated SCZ patients, and 30 age- and gender-matched healthy controls. Strong correlation was observed among the six CpG sites (r>0.5, P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0089128