Synthesis and biological properties of fungal glucosylceramide
Once inside phagocytic cells, C. neoformans can either survive and replicate in the phagolysome, or it can once again reach the extracellular space by exiting these cells without killing them [7], [8]. Since the extracellular environment is neutral/alkaline whereas the intracellular (phagolysosome...
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| Veröffentlicht in: | PLoS pathogens 2014-01, Vol.10 (1), p.e1003832-e1003832 |
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| creator | Del Poeta, Maurizio Nimrichter, Leonardo Rodrigues, Marcio L Luberto, Chiara |
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Once inside phagocytic cells, C. neoformans can either survive and replicate in the phagolysome, or it can once again reach the extracellular space by exiting these cells without killing them [7], [8]. Since the extracellular environment is neutral/alkaline whereas the intracellular (phagolysosome) is acidic, adaptation of C. neoformans to both environments is a critical feature for its survival and virulence in the host. [...]fungal GlcCer is a virulence determinant with a characteristic chemical structure and synthesized by fungal specific enzymes. Since it is produced by a variety of pathogenic fungi, targeting fungal GlcCer should improve the outcome of fungal infection diseases. |
| doi_str_mv | 10.1371/journal.ppat.1003832 |
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Once inside phagocytic cells, C. neoformans can either survive and replicate in the phagolysome, or it can once again reach the extracellular space by exiting these cells without killing them [7], [8]. Since the extracellular environment is neutral/alkaline whereas the intracellular (phagolysosome) is acidic, adaptation of C. neoformans to both environments is a critical feature for its survival and virulence in the host. [...]fungal GlcCer is a virulence determinant with a characteristic chemical structure and synthesized by fungal specific enzymes. Since it is produced by a variety of pathogenic fungi, targeting fungal GlcCer should improve the outcome of fungal infection diseases.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1003832</identifier><identifier>PMID: 24415933</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amides ; Biosynthesis ; Cell division ; Enzymes ; Fungi ; Fungi - metabolism ; Fungi - pathogenicity ; Fungi, Pathogenic ; Glucose ; Glucosylceramides - metabolism ; Health aspects ; Infections ; Microbiological research ; Pearls</subject><ispartof>PLoS pathogens, 2014-01, Vol.10 (1), p.e1003832-e1003832</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Del Poeta et al 2014 Del Poeta et al</rights><rights>2014 Del Poeta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Del Poeta M, Nimrichter L, Rodrigues ML, Luberto C (2014) Synthesis and Biological Properties of Fungal Glucosylceramide. PLoS Pathog 10(1): e1003832. doi:10.1371/journal.ppat.1003832</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c699t-5cc8c65513ab3fc397023705289ac61ffebabb5ccdea2e7104df2696288b067f3</citedby><cites>FETCH-LOGICAL-c699t-5cc8c65513ab3fc397023705289ac61ffebabb5ccdea2e7104df2696288b067f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887071/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887071/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24415933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Heitman, Joseph</contributor><creatorcontrib>Del Poeta, Maurizio</creatorcontrib><creatorcontrib>Nimrichter, Leonardo</creatorcontrib><creatorcontrib>Rodrigues, Marcio L</creatorcontrib><creatorcontrib>Luberto, Chiara</creatorcontrib><title>Synthesis and biological properties of fungal glucosylceramide</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>
Once inside phagocytic cells, C. neoformans can either survive and replicate in the phagolysome, or it can once again reach the extracellular space by exiting these cells without killing them [7], [8]. Since the extracellular environment is neutral/alkaline whereas the intracellular (phagolysosome) is acidic, adaptation of C. neoformans to both environments is a critical feature for its survival and virulence in the host. [...]fungal GlcCer is a virulence determinant with a characteristic chemical structure and synthesized by fungal specific enzymes. Since it is produced by a variety of pathogenic fungi, targeting fungal GlcCer should improve the outcome of fungal infection diseases.</description><subject>Amides</subject><subject>Biosynthesis</subject><subject>Cell division</subject><subject>Enzymes</subject><subject>Fungi</subject><subject>Fungi - metabolism</subject><subject>Fungi - pathogenicity</subject><subject>Fungi, Pathogenic</subject><subject>Glucose</subject><subject>Glucosylceramides - metabolism</subject><subject>Health aspects</subject><subject>Infections</subject><subject>Microbiological research</subject><subject>Pearls</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqVkk1v3CAQhq2qVZNs-w-qdqVc0sNuwWAMl0hR1I-VolZq2jMCPDisWOOCXXX_fdmsE8VSLxUH0PDMy8zLFMUbjNaY1PjDNoyxU37d92pYY4QIJ-Wz4hRXFVnVpKbPn5xPirOUtghRTDB7WZyUlOJKEHJaXN7uu-EOkktL1TVL7YIPrTPKL_sYeoiDg7QMdmnHrs3B1o8mpL03ENXONfCqeGGVT_B62hfFz08ff1x_Wd18-7y5vrpZGSbEsKqM4YZVFSZKE2uIqFFJalSVXCjDsLWgldaZakCVUGNEG1sywUrONWK1JYvi3VG39yHJqfUkMRWciFJwlInNkWiC2so-up2KexmUk_eBEFupcjfGgxS8LoViFQBrKNNCYIMxaC2MtgxykYvicnpt1DtoDHRDVH4mOr_p3J1sw29JOK9RfRC4mARi-DVCGuTOJQPeqw7CeF83yhZwVGX0_Ihme0G6zoasaA64vCKM8ooSyjO1_geVVwM7Z0IH1uX4LOH9LCEzA_wZWjWmJDe33_-D_Tpn6ZE1MaQUwT66gpE8zOXD58jDXMppLnPa26eOPiY9DCL5CwSg3zQ</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Del Poeta, Maurizio</creator><creator>Nimrichter, Leonardo</creator><creator>Rodrigues, Marcio L</creator><creator>Luberto, Chiara</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140101</creationdate><title>Synthesis and biological properties of fungal glucosylceramide</title><author>Del Poeta, Maurizio ; Nimrichter, Leonardo ; Rodrigues, Marcio L ; Luberto, Chiara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c699t-5cc8c65513ab3fc397023705289ac61ffebabb5ccdea2e7104df2696288b067f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Amides</topic><topic>Biosynthesis</topic><topic>Cell division</topic><topic>Enzymes</topic><topic>Fungi</topic><topic>Fungi - metabolism</topic><topic>Fungi - pathogenicity</topic><topic>Fungi, Pathogenic</topic><topic>Glucose</topic><topic>Glucosylceramides - metabolism</topic><topic>Health aspects</topic><topic>Infections</topic><topic>Microbiological research</topic><topic>Pearls</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Del Poeta, Maurizio</creatorcontrib><creatorcontrib>Nimrichter, Leonardo</creatorcontrib><creatorcontrib>Rodrigues, Marcio L</creatorcontrib><creatorcontrib>Luberto, Chiara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Del Poeta, Maurizio</au><au>Nimrichter, Leonardo</au><au>Rodrigues, Marcio L</au><au>Luberto, Chiara</au><au>Heitman, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and biological properties of fungal glucosylceramide</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>10</volume><issue>1</issue><spage>e1003832</spage><epage>e1003832</epage><pages>e1003832-e1003832</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>
Once inside phagocytic cells, C. neoformans can either survive and replicate in the phagolysome, or it can once again reach the extracellular space by exiting these cells without killing them [7], [8]. Since the extracellular environment is neutral/alkaline whereas the intracellular (phagolysosome) is acidic, adaptation of C. neoformans to both environments is a critical feature for its survival and virulence in the host. [...]fungal GlcCer is a virulence determinant with a characteristic chemical structure and synthesized by fungal specific enzymes. Since it is produced by a variety of pathogenic fungi, targeting fungal GlcCer should improve the outcome of fungal infection diseases.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24415933</pmid><doi>10.1371/journal.ppat.1003832</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Amides Biosynthesis Cell division Enzymes Fungi Fungi - metabolism Fungi - pathogenicity Fungi, Pathogenic Glucose Glucosylceramides - metabolism Health aspects Infections Microbiological research Pearls |
| title | Synthesis and biological properties of fungal glucosylceramide |
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