An Asp7Gly substitution in PPARG is associated with decreased transcriptional activation activity

As the master regulator of adipogenesis, peroxisome proliferator-activated receptor gamma (PPARG) is required for the accumulation of adipose tissue and hence contributes to obesity. A previous study showed that the substitution of +20A>G in PPARG changed the 7(th) amino acid from Asp to Gly, cre...

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Veröffentlicht in:	PloS one 2014-01, Vol.9 (1), p.e86954-e86954
Hauptverfasser:	Hua, Liushuai, Wang, Jing, Li, Mingxun, Sun, Xiaomei, Zhang, Liangzhi, Lei, Chuzhao, Lan, Xianyong, Fang, Xingtang, Zhao, Xin, Chen, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - cytology Adipocytes - metabolism Adipogenesis Adipogenesis - physiology Adipose Tissue Agriculture Amino acid substitution Animal husbandry Animal sciences Animals Association analysis Beef cattle Bioaccumulation Biology Body Height Body mass index Body measurements Body Weight Bovidae Breeding Cattle Cell death Cell Differentiation Diabetes Gene expression Genetic aspects Genomes Glycine Homeostasis Humans Insulin Laboratories Livestock breeding Luciferase Luciferases Medicine Mice Molecular biology Mutation Mutation - genetics NIH 3T3 Cells Obesity Peroxisome proliferator-activated receptors PPAR gamma - genetics Promoter Regions, Genetic - genetics Proteins - genetics RNA Studies Substitutes Transcription (Genetics) Transcription activation Transcription, Genetic Type 2 diabetes Veterinary Science Zoology
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Zusammenfassung:	As the master regulator of adipogenesis, peroxisome proliferator-activated receptor gamma (PPARG) is required for the accumulation of adipose tissue and hence contributes to obesity. A previous study showed that the substitution of +20A>G in PPARG changed the 7(th) amino acid from Asp to Gly, creating a mutant referred to as PPARG Asp7Gly. In this study, association analysis indicated that PPARG Asp7Gly was associated with lower body height, body weight and heart girth in cattle (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0086954