The AmAZI1ng roles of centriolar satellites during development
Given the high conservation of Azi1 among ciliated organisms, the loss-of-function phenotypes from various model organisms, as well as the siRNA results, it was safe to predict that Azi1 would have a central role in mammalian cilia biology in vivo. [...]the authors generated mouse mutants null for...
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| Veröffentlicht in: | PLoS genetics 2013-12, Vol.9 (12), p.e1004070-e1004070 |
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| creator | Mahjoub, Moe R Tsou, Meng-Fu Bryan |
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Given the high conservation of Azi1 among ciliated organisms, the loss-of-function phenotypes from various model organisms, as well as the siRNA results, it was safe to predict that Azi1 would have a central role in mammalian cilia biology in vivo. [...]the authors generated mouse mutants null for Azi1 to test the role of this protein (and centriolar satellites) in mammalian development. [...]this study also highlights the importance of functional follow-up studies of siRNA-based data and cautions against direct extrapolation of transient loss-of-function phenotypes to the genetic in vivo phenotype. |
| doi_str_mv | 10.1371/journal.pgen.1004070 |
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Given the high conservation of Azi1 among ciliated organisms, the loss-of-function phenotypes from various model organisms, as well as the siRNA results, it was safe to predict that Azi1 would have a central role in mammalian cilia biology in vivo. [...]the authors generated mouse mutants null for Azi1 to test the role of this protein (and centriolar satellites) in mammalian development. [...]this study also highlights the importance of functional follow-up studies of siRNA-based data and cautions against direct extrapolation of transient loss-of-function phenotypes to the genetic in vivo phenotype.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.1004070</identifier><identifier>PMID: 24385938</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Cells ; Centrioles - genetics ; Centrosome - metabolism ; Cilia - genetics ; Cilia - metabolism ; Compensation ; Defects ; Genotype & phenotype ; Humans ; Ligands (Biochemistry) ; Mice ; Microtubules - genetics ; Physiological aspects ; Proteins ; Proteins - genetics ; Proteins - metabolism ; RNA, Small Interfering ; Rodents ; Satellites ; Sperm ; Studies</subject><ispartof>PLoS genetics, 2013-12, Vol.9 (12), p.e1004070-e1004070</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Mahjoub, Tsou 2013 Mahjoub, Tsou</rights><rights>2013 Mahjoub, Tsou. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Mahjoub MR, Tsou M-FB (2013) The AmAZI1ng Roles of Centriolar Satellites during Development. PLoS Genet 9(12): e1004070. doi:10.1371/journal.pgen.1004070</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c698t-f0ec886399291d56bfeb70a6e641365d90ac62b66d4ce6a10c25bc2825a8b1d63</citedby><cites>FETCH-LOGICAL-c698t-f0ec886399291d56bfeb70a6e641365d90ac62b66d4ce6a10c25bc2825a8b1d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873264/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873264/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24385938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahjoub, Moe R</creatorcontrib><creatorcontrib>Tsou, Meng-Fu Bryan</creatorcontrib><title>The AmAZI1ng roles of centriolar satellites during development</title><title>PLoS genetics</title><addtitle>PLoS Genet</addtitle><description>
Given the high conservation of Azi1 among ciliated organisms, the loss-of-function phenotypes from various model organisms, as well as the siRNA results, it was safe to predict that Azi1 would have a central role in mammalian cilia biology in vivo. [...]the authors generated mouse mutants null for Azi1 to test the role of this protein (and centriolar satellites) in mammalian development. [...]this study also highlights the importance of functional follow-up studies of siRNA-based data and cautions against direct extrapolation of transient loss-of-function phenotypes to the genetic in vivo phenotype.</description><subject>Animals</subject><subject>Cells</subject><subject>Centrioles - genetics</subject><subject>Centrosome - metabolism</subject><subject>Cilia - genetics</subject><subject>Cilia - metabolism</subject><subject>Compensation</subject><subject>Defects</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Ligands (Biochemistry)</subject><subject>Mice</subject><subject>Microtubules - genetics</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Proteins - genetics</subject><subject>Proteins - metabolism</subject><subject>RNA, Small Interfering</subject><subject>Rodents</subject><subject>Satellites</subject><subject>Sperm</subject><subject>Studies</subject><issn>1553-7404</issn><issn>1553-7390</issn><issn>1553-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqVkl1rFDEUhgdRbK3-A9EFQfRi12TyfVNYih8LxYJWL7wJmXzMZslM1mSm6L83292WHfBCyUXCOc95c3LyVtVzCBYQMfhuE8fUq7DYtrZfQAAwYOBBdQoJQXOGAX54dD6pnuS8AQARLtjj6qTGiBOB-Gl1fr22s2W3_LGCfTtLMdg8i26mbT8kH4NKs6wGG4IfSsKMyRfK2Bsb4rYrzNPqkVMh22eH_az69uH99cWn-eXVx9XF8nKuqeDD3AGrOadIiFpAQ2jjbMOAopZiiCgxAihN64ZSg7WlCgJdk0bXvCaKN9BQdFa93OtuQ8zy8PQsIWZMEFxzWIjVnjBRbeQ2-U6l3zIqL28DMbVSpcHrYKVrLBOU8Vo1GjcM8QYLY5yhzqnaEFO0zg-3jU1nze0wVJiITjO9X8s23kjEGaopLgJvDgIp_hxtHmTnsy5jVL2N465vARisqRAFfbVHW1Va872LRVHvcLlEhJWhMYYKtfgLVZaxndext86X-KTg7aSgMIP9NbRqzFmuvn75D_bzv7NX36fs6yN2bVUY1jmGcfCxz1MQ70GdYs7JuvtRQyB3Zr_7cbkzuzyYvZS9OP6m-6I7d6M_cbf5UQ</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Mahjoub, Moe R</creator><creator>Tsou, Meng-Fu Bryan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131201</creationdate><title>The AmAZI1ng roles of centriolar satellites during development</title><author>Mahjoub, Moe R ; Tsou, Meng-Fu Bryan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c698t-f0ec886399291d56bfeb70a6e641365d90ac62b66d4ce6a10c25bc2825a8b1d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Cells</topic><topic>Centrioles - genetics</topic><topic>Centrosome - metabolism</topic><topic>Cilia - genetics</topic><topic>Cilia - metabolism</topic><topic>Compensation</topic><topic>Defects</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Ligands (Biochemistry)</topic><topic>Mice</topic><topic>Microtubules - genetics</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Proteins - genetics</topic><topic>Proteins - metabolism</topic><topic>RNA, Small Interfering</topic><topic>Rodents</topic><topic>Satellites</topic><topic>Sperm</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahjoub, Moe R</creatorcontrib><creatorcontrib>Tsou, Meng-Fu Bryan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahjoub, Moe R</au><au>Tsou, Meng-Fu Bryan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The AmAZI1ng roles of centriolar satellites during development</atitle><jtitle>PLoS genetics</jtitle><addtitle>PLoS Genet</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>9</volume><issue>12</issue><spage>e1004070</spage><epage>e1004070</epage><pages>e1004070-e1004070</pages><issn>1553-7404</issn><issn>1553-7390</issn><eissn>1553-7404</eissn><abstract>
Given the high conservation of Azi1 among ciliated organisms, the loss-of-function phenotypes from various model organisms, as well as the siRNA results, it was safe to predict that Azi1 would have a central role in mammalian cilia biology in vivo. [...]the authors generated mouse mutants null for Azi1 to test the role of this protein (and centriolar satellites) in mammalian development. [...]this study also highlights the importance of functional follow-up studies of siRNA-based data and cautions against direct extrapolation of transient loss-of-function phenotypes to the genetic in vivo phenotype.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24385938</pmid><doi>10.1371/journal.pgen.1004070</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cells Centrioles - genetics Centrosome - metabolism Cilia - genetics Cilia - metabolism Compensation Defects Genotype & phenotype Humans Ligands (Biochemistry) Mice Microtubules - genetics Physiological aspects Proteins Proteins - genetics Proteins - metabolism RNA, Small Interfering Rodents Satellites Sperm Studies |
| title | The AmAZI1ng roles of centriolar satellites during development |
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