Aspergillus fumigatus--what makes the species a ubiquitous human fungal pathogen?

Since gliotoxin is immunosuppressive and cytocidal [17], it can be speculated that the fungus benefits from nutrients released by the gliotoxin-destroyed host cells. Concluding Remarks Among the over 200 species of Aspergillus, A. fumigatus is the best at meeting the four features discussed in thi...

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Veröffentlicht in:	PLoS pathogens 2013-12, Vol.9 (12), p.e1003743-e1003743
Hauptverfasser:	Kwon-Chung, Kyung J, Sugui, Janyce A
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Air Aspergillosis - epidemiology Aspergillosis - microbiology Aspergillus Aspergillus fumigatus - growth & development Aspergillus fumigatus - pathogenicity Composting Environment Fungi Gene expression Genomes Health aspects Humans Infections Metabolites Microbiological research Nitrogen Pearls Physiological aspects Respiratory Tract Infections - epidemiology Respiratory Tract Infections - microbiology Spores, Fungal - growth & development Spores, Fungal - physiology Stem cells
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Zusammenfassung:	Since gliotoxin is immunosuppressive and cytocidal [17], it can be speculated that the fungus benefits from nutrients released by the gliotoxin-destroyed host cells. Concluding Remarks Among the over 200 species of Aspergillus, A. fumigatus is the best at meeting the four features discussed in this review. Since innate immunity protects against Aspergillus, the reason for the wide spread of IA caused by A. fumigatus is due to the global distribution of both the fungus and an increase in susceptible hosts.
ISSN:	1553-7374 1553-7366 1553-7374
DOI:	10.1371/journal.ppat.1003743