Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma
Many studies have shown that magnetic fields (MF) inhibit tumor growth and influence the function of immune system. However, the effect of MF on mechanism of immunological function in tumor-bearing mice is still unclear. In this study, tumor-bearing mice were prepared by subcutaneously inoculating B...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-11, Vol.8 (11), p.e72411-e72411 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e72411 |
|---|---|
| container_issue | 11 |
| container_start_page | e72411 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Nie, Yunzhong Chen, Yueqiu Mou, Yongbin Weng, Leihua Xu, Zhenjun Du, Youwei Wang, Wenmei Hou, Yayi Wang, Tingting |
| description | Many studies have shown that magnetic fields (MF) inhibit tumor growth and influence the function of immune system. However, the effect of MF on mechanism of immunological function in tumor-bearing mice is still unclear.
In this study, tumor-bearing mice were prepared by subcutaneously inoculating Balb/c mice with hepatocarcinoma cell line H22. The mice were then exposed to a low frequency MF (0.4 T, 7.5 Hz) for 30 days. Survival rate, tumor growth and the innate and adaptive immune parameters were measured.
MF treatment could prolong survival time (n = 28, p |
| doi_str_mv | 10.1371/journal.pone.0072411 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1460161287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478186325</galeid><doaj_id>oai_doaj_org_article_6efa65d4059543dfb44d49bad8855ed9</doaj_id><sourcerecordid>A478186325</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-3acaa7128f12d758b42987da1c16dac1767c0a545cea8d80aa66d0fb47538ded3</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rr6D0QLgujFjPlqmt4Iy6LuwMCCX7fhTJJ2MrTJmKTq_nszTnfZyl5IL9okz3lPz3tyiuI5RktMa_xu58fgoF_uvTNLhGrCMH5QnOKGkgUniD68831SPIlxh1BFBeePixPCSC0woqfFbu1_lW0wP0bj1HU5QOdMsqpsrel1LI3bglOmBJdsGgcfSjsMozNlMDEnjvmkA-tiKgc_5tUlIeXW7CF5Zfp-7CGUCoKyzg_wtHjUQh_Ns-l9Vnz7-OHrxeViffVpdXG-XijekLSgoABqTESLia4rsWGkEbUGrDDXoHDNa4WgYpUyILRAAJxr1G5YnavTRtOz4uVRd9_7KCebosSMI8yzbp2J1ZHQHnZyH-wA4Vp6sPLvhg-dhJBd6I3kpgVeaYaqpmJU5zRMs2YDWoiqMrrJWu-nbONmMFoZlwL0M9H5ibNb2fmfkgpaiYZkgTeTQPC5CzHJwcaDe-BM9vTw3wQLjjHO6Kt_0Purm6gOcgHWtT7nVQdRec5y2wWnpMrU8h4qP9oMVuU71dq8Pwt4OwvITDK_UwdjjHL15fP_s1ff5-zrO-zWQJ-20fdjsvl-zUF2BFXwMQbT3pqMkTyMxI0b8jASchqJHPbiboNug25mgP4B7zQH-w</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1460161287</pqid></control><display><type>article</type><title>Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Nie, Yunzhong ; Chen, Yueqiu ; Mou, Yongbin ; Weng, Leihua ; Xu, Zhenjun ; Du, Youwei ; Wang, Wenmei ; Hou, Yayi ; Wang, Tingting</creator><creatorcontrib>Nie, Yunzhong ; Chen, Yueqiu ; Mou, Yongbin ; Weng, Leihua ; Xu, Zhenjun ; Du, Youwei ; Wang, Wenmei ; Hou, Yayi ; Wang, Tingting</creatorcontrib><description>Many studies have shown that magnetic fields (MF) inhibit tumor growth and influence the function of immune system. However, the effect of MF on mechanism of immunological function in tumor-bearing mice is still unclear.
In this study, tumor-bearing mice were prepared by subcutaneously inoculating Balb/c mice with hepatocarcinoma cell line H22. The mice were then exposed to a low frequency MF (0.4 T, 7.5 Hz) for 30 days. Survival rate, tumor growth and the innate and adaptive immune parameters were measured.
MF treatment could prolong survival time (n = 28, p<0.05) and inhibit tumor growth (n = 9, p<0.01) in tumor-bearing mice. Moreover, this MF suppressed tumor-induced production of cytokines including interleukin-6 (IL-6), granulocyte colony- stimulating factor (G-CSF) and keratinocyte-derived chemokine (KC) (n = 9-10, p<0.05 or 0.01). Furthermore, MF exposure was associated with activation of macrophages and dendritic cells, enhanced profiles of CD4(+) T and CD8(+) T lymphocytes, the balance of Th17/Treg and reduced inhibitory function of Treg cells (n = 9-10, p<0.05 or 0.01) in the mice model.
The inhibitory effect of MF on tumor growth was related to the improvement of immune function in the tumor-bearing mice.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0072411</identifier><identifier>PMID: 24278103</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptive Immunity - physiology ; Animals ; Antitumor activity ; Bearing ; Cancer ; Cancer treatment ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - immunology ; Carcinoma, Hepatocellular - therapy ; CD4 antigen ; CD8 antigen ; Cell activation ; Cell Line, Tumor ; Cell Survival - physiology ; Cytokines ; Cytokines - blood ; Dendritic cells ; Female ; Flow Cytometry ; Granulocyte colony-stimulating factor ; Helper cells ; Hepatocellular carcinoma ; Immune response ; Immune system ; Immunity, Innate - physiology ; Immunohistochemistry ; Immunology ; Interleukin ; Interleukin 6 ; Interleukins ; Leukocytes (granulocytic) ; Liver cancer ; Liver Neoplasms - blood ; Liver Neoplasms - immunology ; Liver Neoplasms - therapy ; Low frequencies ; Lymphocytes ; Lymphocytes T ; Macrophages ; Magnetic Fields ; Mice ; Mice, Inbred BALB C ; Mortality ; Real-Time Polymerase Chain Reaction ; Rodents ; Studies ; Survival ; T cells ; T-Lymphocytes - immunology</subject><ispartof>PloS one, 2013-11, Vol.8 (11), p.e72411-e72411</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Nie et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Nie et al 2013 Nie et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3acaa7128f12d758b42987da1c16dac1767c0a545cea8d80aa66d0fb47538ded3</citedby><cites>FETCH-LOGICAL-c692t-3acaa7128f12d758b42987da1c16dac1767c0a545cea8d80aa66d0fb47538ded3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835892/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835892/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24278103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nie, Yunzhong</creatorcontrib><creatorcontrib>Chen, Yueqiu</creatorcontrib><creatorcontrib>Mou, Yongbin</creatorcontrib><creatorcontrib>Weng, Leihua</creatorcontrib><creatorcontrib>Xu, Zhenjun</creatorcontrib><creatorcontrib>Du, Youwei</creatorcontrib><creatorcontrib>Wang, Wenmei</creatorcontrib><creatorcontrib>Hou, Yayi</creatorcontrib><creatorcontrib>Wang, Tingting</creatorcontrib><title>Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Many studies have shown that magnetic fields (MF) inhibit tumor growth and influence the function of immune system. However, the effect of MF on mechanism of immunological function in tumor-bearing mice is still unclear.
In this study, tumor-bearing mice were prepared by subcutaneously inoculating Balb/c mice with hepatocarcinoma cell line H22. The mice were then exposed to a low frequency MF (0.4 T, 7.5 Hz) for 30 days. Survival rate, tumor growth and the innate and adaptive immune parameters were measured.
MF treatment could prolong survival time (n = 28, p<0.05) and inhibit tumor growth (n = 9, p<0.01) in tumor-bearing mice. Moreover, this MF suppressed tumor-induced production of cytokines including interleukin-6 (IL-6), granulocyte colony- stimulating factor (G-CSF) and keratinocyte-derived chemokine (KC) (n = 9-10, p<0.05 or 0.01). Furthermore, MF exposure was associated with activation of macrophages and dendritic cells, enhanced profiles of CD4(+) T and CD8(+) T lymphocytes, the balance of Th17/Treg and reduced inhibitory function of Treg cells (n = 9-10, p<0.05 or 0.01) in the mice model.
The inhibitory effect of MF on tumor growth was related to the improvement of immune function in the tumor-bearing mice.</description><subject>Adaptive Immunity - physiology</subject><subject>Animals</subject><subject>Antitumor activity</subject><subject>Bearing</subject><subject>Cancer</subject><subject>Cancer treatment</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - immunology</subject><subject>Carcinoma, Hepatocellular - therapy</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>Cell activation</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - physiology</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Dendritic cells</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Granulocyte colony-stimulating factor</subject><subject>Helper cells</subject><subject>Hepatocellular carcinoma</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity, Innate - physiology</subject><subject>Immunohistochemistry</subject><subject>Immunology</subject><subject>Interleukin</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Leukocytes (granulocytic)</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - immunology</subject><subject>Liver Neoplasms - therapy</subject><subject>Low frequencies</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Magnetic Fields</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mortality</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Rodents</subject><subject>Studies</subject><subject>Survival</subject><subject>T cells</subject><subject>T-Lymphocytes - immunology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLgujFjPlqmt4Iy6LuwMCCX7fhTJJ2MrTJmKTq_nszTnfZyl5IL9okz3lPz3tyiuI5RktMa_xu58fgoF_uvTNLhGrCMH5QnOKGkgUniD68831SPIlxh1BFBeePixPCSC0woqfFbu1_lW0wP0bj1HU5QOdMsqpsrel1LI3bglOmBJdsGgcfSjsMozNlMDEnjvmkA-tiKgc_5tUlIeXW7CF5Zfp-7CGUCoKyzg_wtHjUQh_Ns-l9Vnz7-OHrxeViffVpdXG-XijekLSgoABqTESLia4rsWGkEbUGrDDXoHDNa4WgYpUyILRAAJxr1G5YnavTRtOz4uVRd9_7KCebosSMI8yzbp2J1ZHQHnZyH-wA4Vp6sPLvhg-dhJBd6I3kpgVeaYaqpmJU5zRMs2YDWoiqMrrJWu-nbONmMFoZlwL0M9H5ibNb2fmfkgpaiYZkgTeTQPC5CzHJwcaDe-BM9vTw3wQLjjHO6Kt_0Purm6gOcgHWtT7nVQdRec5y2wWnpMrU8h4qP9oMVuU71dq8Pwt4OwvITDK_UwdjjHL15fP_s1ff5-zrO-zWQJ-20fdjsvl-zUF2BFXwMQbT3pqMkTyMxI0b8jASchqJHPbiboNug25mgP4B7zQH-w</recordid><startdate>20131120</startdate><enddate>20131120</enddate><creator>Nie, Yunzhong</creator><creator>Chen, Yueqiu</creator><creator>Mou, Yongbin</creator><creator>Weng, Leihua</creator><creator>Xu, Zhenjun</creator><creator>Du, Youwei</creator><creator>Wang, Wenmei</creator><creator>Hou, Yayi</creator><creator>Wang, Tingting</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131120</creationdate><title>Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma</title><author>Nie, Yunzhong ; Chen, Yueqiu ; Mou, Yongbin ; Weng, Leihua ; Xu, Zhenjun ; Du, Youwei ; Wang, Wenmei ; Hou, Yayi ; Wang, Tingting</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3acaa7128f12d758b42987da1c16dac1767c0a545cea8d80aa66d0fb47538ded3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adaptive Immunity - physiology</topic><topic>Animals</topic><topic>Antitumor activity</topic><topic>Bearing</topic><topic>Cancer</topic><topic>Cancer treatment</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - immunology</topic><topic>Carcinoma, Hepatocellular - therapy</topic><topic>CD4 antigen</topic><topic>CD8 antigen</topic><topic>Cell activation</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - physiology</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Dendritic cells</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Granulocyte colony-stimulating factor</topic><topic>Helper cells</topic><topic>Hepatocellular carcinoma</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity, Innate - physiology</topic><topic>Immunohistochemistry</topic><topic>Immunology</topic><topic>Interleukin</topic><topic>Interleukin 6</topic><topic>Interleukins</topic><topic>Leukocytes (granulocytic)</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - immunology</topic><topic>Liver Neoplasms - therapy</topic><topic>Low frequencies</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Magnetic Fields</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mortality</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Rodents</topic><topic>Studies</topic><topic>Survival</topic><topic>T cells</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nie, Yunzhong</creatorcontrib><creatorcontrib>Chen, Yueqiu</creatorcontrib><creatorcontrib>Mou, Yongbin</creatorcontrib><creatorcontrib>Weng, Leihua</creatorcontrib><creatorcontrib>Xu, Zhenjun</creatorcontrib><creatorcontrib>Du, Youwei</creatorcontrib><creatorcontrib>Wang, Wenmei</creatorcontrib><creatorcontrib>Hou, Yayi</creatorcontrib><creatorcontrib>Wang, Tingting</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale in Context : Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nie, Yunzhong</au><au>Chen, Yueqiu</au><au>Mou, Yongbin</au><au>Weng, Leihua</au><au>Xu, Zhenjun</au><au>Du, Youwei</au><au>Wang, Wenmei</au><au>Hou, Yayi</au><au>Wang, Tingting</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-11-20</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><spage>e72411</spage><epage>e72411</epage><pages>e72411-e72411</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Many studies have shown that magnetic fields (MF) inhibit tumor growth and influence the function of immune system. However, the effect of MF on mechanism of immunological function in tumor-bearing mice is still unclear.
In this study, tumor-bearing mice were prepared by subcutaneously inoculating Balb/c mice with hepatocarcinoma cell line H22. The mice were then exposed to a low frequency MF (0.4 T, 7.5 Hz) for 30 days. Survival rate, tumor growth and the innate and adaptive immune parameters were measured.
MF treatment could prolong survival time (n = 28, p<0.05) and inhibit tumor growth (n = 9, p<0.01) in tumor-bearing mice. Moreover, this MF suppressed tumor-induced production of cytokines including interleukin-6 (IL-6), granulocyte colony- stimulating factor (G-CSF) and keratinocyte-derived chemokine (KC) (n = 9-10, p<0.05 or 0.01). Furthermore, MF exposure was associated with activation of macrophages and dendritic cells, enhanced profiles of CD4(+) T and CD8(+) T lymphocytes, the balance of Th17/Treg and reduced inhibitory function of Treg cells (n = 9-10, p<0.05 or 0.01) in the mice model.
The inhibitory effect of MF on tumor growth was related to the improvement of immune function in the tumor-bearing mice.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24278103</pmid><doi>10.1371/journal.pone.0072411</doi><tpages>e72411</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-11, Vol.8 (11), p.e72411-e72411 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1460161287 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adaptive Immunity - physiology Animals Antitumor activity Bearing Cancer Cancer treatment Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - therapy CD4 antigen CD8 antigen Cell activation Cell Line, Tumor Cell Survival - physiology Cytokines Cytokines - blood Dendritic cells Female Flow Cytometry Granulocyte colony-stimulating factor Helper cells Hepatocellular carcinoma Immune response Immune system Immunity, Innate - physiology Immunohistochemistry Immunology Interleukin Interleukin 6 Interleukins Leukocytes (granulocytic) Liver cancer Liver Neoplasms - blood Liver Neoplasms - immunology Liver Neoplasms - therapy Low frequencies Lymphocytes Lymphocytes T Macrophages Magnetic Fields Mice Mice, Inbred BALB C Mortality Real-Time Polymerase Chain Reaction Rodents Studies Survival T cells T-Lymphocytes - immunology |
| title | Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T23%3A38%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20frequency%20magnetic%20fields%20enhance%20antitumor%20immune%20response%20against%20mouse%20H22%20hepatocellular%20carcinoma&rft.jtitle=PloS%20one&rft.au=Nie,%20Yunzhong&rft.date=2013-11-20&rft.volume=8&rft.issue=11&rft.spage=e72411&rft.epage=e72411&rft.pages=e72411-e72411&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0072411&rft_dat=%3Cgale_plos_%3EA478186325%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1460161287&rft_id=info:pmid/24278103&rft_galeid=A478186325&rft_doaj_id=oai_doaj_org_article_6efa65d4059543dfb44d49bad8855ed9&rfr_iscdi=true |