Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma

Many studies have shown that magnetic fields (MF) inhibit tumor growth and influence the function of immune system. However, the effect of MF on mechanism of immunological function in tumor-bearing mice is still unclear. In this study, tumor-bearing mice were prepared by subcutaneously inoculating B...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e72411-e72411
Hauptverfasser:	Nie, Yunzhong, Chen, Yueqiu, Mou, Yongbin, Weng, Leihua, Xu, Zhenjun, Du, Youwei, Wang, Wenmei, Hou, Yayi, Wang, Tingting
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - physiology Animals Antitumor activity Bearing Cancer Cancer treatment Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - therapy CD4 antigen CD8 antigen Cell activation Cell Line, Tumor Cell Survival - physiology Cytokines Cytokines - blood Dendritic cells Female Flow Cytometry Granulocyte colony-stimulating factor Helper cells Hepatocellular carcinoma Immune response Immune system Immunity, Innate - physiology Immunohistochemistry Immunology Interleukin Interleukin 6 Interleukins Leukocytes (granulocytic) Liver cancer Liver Neoplasms - blood Liver Neoplasms - immunology Liver Neoplasms - therapy Low frequencies Lymphocytes Lymphocytes T Macrophages Magnetic Fields Mice Mice, Inbred BALB C Mortality Real-Time Polymerase Chain Reaction Rodents Studies Survival T cells T-Lymphocytes - immunology
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Zusammenfassung:	Many studies have shown that magnetic fields (MF) inhibit tumor growth and influence the function of immune system. However, the effect of MF on mechanism of immunological function in tumor-bearing mice is still unclear. In this study, tumor-bearing mice were prepared by subcutaneously inoculating Balb/c mice with hepatocarcinoma cell line H22. The mice were then exposed to a low frequency MF (0.4 T, 7.5 Hz) for 30 days. Survival rate, tumor growth and the innate and adaptive immune parameters were measured. MF treatment could prolong survival time (n = 28, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0072411