Whole genome analysis of epidemiologically closely related Staphylococcus aureus isolates

Whole genome analysis of epidemiologically closely related Staphylococcus aureus isolates

The change of the bacteria from colonizers to pathogens is accompanied by a drastic change in expression profiles. These changes may be due to environmental signals or to mutational changes. We therefore compared the whole genome sequences of four sets of S. aureus isolates. Three sets were from the...

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Veröffentlicht in:PloS one 2013-10, Vol.8 (10), p.e78340-e78340
Hauptverfasser: Schijffelen, Maarten, Konstantinov, Sergey R, Lina, Gérard, Spiliopoulou, Iris, van Duijkeren, Engeline, Brouwer, Ellen C, Fluit, Ad C
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Animals
Bacteria
Colonization
Cross infection
Drug resistance
Environmental changes
Epidemiology
Gene expression
Gene sequencing
Genes
Genetic aspects
Genome, Bacterial - genetics
Genome-Wide Association Study - methods
Genomes
Genomics
Health aspects
Infections
Membrane proteins
Mutation
Nosocomial infections
Polymorphism, Single Nucleotide - genetics
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Skin
Staphylococcal Infections - microbiology
Staphylococcal Skin Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - genetics
Staphylococcus aureus - isolation & purification
Staphylococcus infections
Streptococcus infections
Swine - microbiology
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Beschreibung
Zusammenfassung:The change of the bacteria from colonizers to pathogens is accompanied by a drastic change in expression profiles. These changes may be due to environmental signals or to mutational changes. We therefore compared the whole genome sequences of four sets of S. aureus isolates. Three sets were from the same patients. The isolates of each pair (S1800/S1805, S2396/S2395, S2398/S2397, an isolate from colonization and an isolate from infection, respectively) were obtained within
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0078340