Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases

Cross-seeding of misfolded proteins: implications for etiology and pathogenesis of protein misfolding diseases

  [...]a wide variety of misfolded structures are formed, ranging from small soluble oligomers to large fibrillar deposits. Since nuclei are formed, the aggregation increases in an exponential manner from small oligomers to fibers.

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Bibliographische Detailangaben
Veröffentlicht in:PLoS pathogens 2013-09, Vol.9 (9), p.e1003537-e1003537
Hauptverfasser: Morales, Rodrigo, Moreno-Gonzalez, Ines, Soto, Claudio
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Disease Models, Animal
Experiments
Humans
Models, Biological
Oxidative stress
Pathogenesis
Pearls
Physiology, Pathological
Polymerization
Prions
Protein Aggregation, Pathological - etiology
Protein Folding
Protein Interaction Domains and Motifs
Proteins - chemistry
Proteostasis Deficiencies - etiology
Proteostasis Deficiencies - physiopathology
Seeds
Signal transduction
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Beschreibung
Zusammenfassung:  [...]a wide variety of misfolded structures are formed, ranging from small soluble oligomers to large fibrillar deposits. Since nuclei are formed, the aggregation increases in an exponential manner from small oligomers to fibers.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003537