Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified

This study aimed at investigating the fecal microbiota and metabolome of children with Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and autism (AD) in comparison to healthy children (HC). Bacterial tag-encoded FLX-titanium amplicon pyrosequencing (bTEFAP) of the 16S rDNA and 16...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76993-e76993
Hauptverfasser:	De Angelis, Maria, Piccolo, Maria, Vannini, Lucia, Siragusa, Sonya, De Giacomo, Andrea, Serrazzanetti, Diana Isabella, Cristofori, Fernanda, Guerzoni, Maria Elisabetta, Gobbetti, Marco, Francavilla, Ruggiero
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Amino acids Amino Acids - metabolism Autism Autistic Disorder - microbiology Bacteria Bacteria - genetics Bacteria - metabolism Bifidobacterium Child Child Development Disorders, Pervasive - microbiology Child, Preschool Children Children & youth Clostridia Coding Communication Desulfovibrio Developmental disabilities Diagnostic systems Diet Discriminant analysis Disease Fecal microflora Feces Feces - microbiology Female Food Humans Interdisciplinary aspects Intestinal microflora Male Medical research Metabolism Metabolites Metabolome Microbiota Microbiota (Symbiotic organisms) Microbiota - genetics Microorganisms Nitric-oxide synthase Nutrition research Organic compounds Rarefaction RNA rRNA 16S Sarcina Sequence Analysis Social interaction Studies Type 2 diabetes VOCs Volatile organic compounds Volatile Organic Compounds - metabolism
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Zusammenfassung:	This study aimed at investigating the fecal microbiota and metabolome of children with Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and autism (AD) in comparison to healthy children (HC). Bacterial tag-encoded FLX-titanium amplicon pyrosequencing (bTEFAP) of the 16S rDNA and 16S rRNA analyses were carried out to determine total bacteria (16S rDNA) and metabolically active bacteria (16S rRNA), respectively. The main bacterial phyla (Firmicutes, Bacteroidetes, Fusobacteria and Verrucomicrobia) significantly (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0076993