MGMT Leu84Phe polymorphism contributes to cancer susceptibility: evidence from 44 case-control studies

O(6)-methylguanine-DNA methyltransferase is one of the few proteins to directly remove alkylating agents in the human DNA direct reversal repair pathway. A large number of case-control studies have been conducted to explore the association between MGMT Leu84Phe polymorphism and cancer risk. However,...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e75367-e75367
Hauptverfasser:	Liu, Jun, Zhang, Renxia, Chen, Fei, Yu, Cuicui, Sun, Yan, Jia, Chuanliang, Zhang, Lijing, Salahuddin, Taufiq, Li, Xiaodong, Lang, Juntian, Song, Xicheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating agents Alkylation Cancer Case-Control Studies Colorectal cancer Colorectal carcinoma Deoxyribonucleic acid DNA DNA damage DNA methyltransferase DNA Modification Methylases - genetics DNA repair DNA Repair Enzymes - genetics Enzymes Ethnicity European Continental Ancestry Group - genetics Genes Genes, Recessive - genetics Genetic Predisposition to Disease - genetics Genotype & phenotype Health risk assessment Health risks Hospitals Humans Lung cancer Lung diseases Medical schools Meta-analysis Methylguanine Models, Genetic Mutation, Missense - genetics Neoplasms - genetics O6-methylguanine-DNA methyltransferase Odds Ratio Otolaryngology Polymorphism Population Proteins Regression Analysis Risk analysis Studies Surgery Tumor Suppressor Proteins - genetics
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Zusammenfassung:	O(6)-methylguanine-DNA methyltransferase is one of the few proteins to directly remove alkylating agents in the human DNA direct reversal repair pathway. A large number of case-control studies have been conducted to explore the association between MGMT Leu84Phe polymorphism and cancer risk. However, the results were not consistent. We carried out a meta-analysis of 44 case-control studies to clarify the association between the Leu84Phe polymorphism and cancer risk. Overall, significant association of the T allele with cancer susceptibility was verified with meta-analysis under a recessive genetic model (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0075367