Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging

Mitochondrial defects are implicated in aging and in a multitude of age-related diseases, such as cancer, heart failure, Parkinson's disease, and Huntington's disease. However, it is still unclear how mitochondrial defects arise under normal physiological conditions. Mitochondrial DNA (mtD...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e73318
Hauptverfasser:	Yang, Jiang-Nan, Seluanov, Andrei, Gorbunova, Vera
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - genetics Aging - physiology Animals Biology Brain Cancer Chordata Coronary artery disease Correlation Defects Deoxyribonucleic acid DNA DNA Replication - genetics DNA Replication - physiology DNA, Mitochondrial - genetics Free radicals Genome, Mitochondrial - genetics Genomes Genomic instability Genomic Instability - genetics Genomics Heart diseases Heart failure Inversions Life span Mammalia Mice Mice, Inbred C57BL Mitochondria Mitochondrial DNA Molecular Sequence Data Mutation Physiological aspects Polymerase Chain Reaction Replication Saccharomyces cerevisiae Sequence Inversion - genetics Signal transduction Stability
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Zusammenfassung:	Mitochondrial defects are implicated in aging and in a multitude of age-related diseases, such as cancer, heart failure, Parkinson's disease, and Huntington's disease. However, it is still unclear how mitochondrial defects arise under normal physiological conditions. Mitochondrial DNA (mtDNA) deletions caused by direct repeats (DRs) are implicated in the formation of mitochondrial defects, however, mitochondrial DRs show relatively weak (Pearson's r = -0.22, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0073318