Predictive value of BRCA1, ERCC1, ATP7B, PKM2, TOPOI, TOPΟ-IIA, TOPOIIB and C-MYC genes in patients with small cell lung cancer (SCLC) who received first line therapy with cisplatin and etoposide

The aim of the study was to evaluate the predictive value of genes involved in the action of cisplatin-etoposide in Small Cell Lung Cancer (SCLC). 184 SCLC patients' primary tumour samples were analyzed for ERCCI, BRCA1, ATP7B, PKM2 TOPOI, TOPOIIA, TOPOIIB and C-MYC mRNA expression. All patient...

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Veröffentlicht in:	PloS one 2013-09, Vol.8 (9), p.e74611
Hauptverfasser:	Karachaliou, Niki, Papadaki, Chara, Lagoudaki, Eleni, Trypaki, Maria, Sfakianaki, Maria, Koutsopoulos, Anastasios, Mavroudis, Dimitris, Stathopoulos, Efstathios, Georgoulias, Vassilis, Souglakos, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adult Aged Antigens, Neoplasm - genetics Biology BRCA1 protein BRCA1 Protein - genetics Breast cancer c-Myc protein Cancer Cancer therapies Carrier Proteins - genetics Cation Transport Proteins - genetics Chemotherapy Cisplatin Cisplatin - pharmacology Cisplatin - therapeutic use Copper-Transporting ATPases Deoxyribonucleic acid Disease-Free Survival DNA DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type II - genetics DNA-Binding Proteins - genetics Endonucleases - genetics ERCC1 protein Etoposide Etoposide - pharmacology Etoposide - therapeutic use Gene amplification Gene expression Gene Expression Regulation, Neoplastic - drug effects Genes Genes, myc Genes, Neoplasm - genetics Hospitals Humans Kinases Laboratories Lung cancer Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Medicine Membrane Proteins - genetics Metastasis Middle Aged Multivariate Analysis Myc protein Oncology Pathology Patients Predictive Value of Tests Proteins Radiation therapy RNA, Messenger - genetics RNA, Messenger - metabolism Serum levels Small cell lung carcinoma Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - genetics Small Cell Lung Carcinoma - pathology Studies Survival Thyroid Hormone-Binding Proteins Thyroid Hormones - genetics Treatment Outcome Tumors
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Zusammenfassung:	The aim of the study was to evaluate the predictive value of genes involved in the action of cisplatin-etoposide in Small Cell Lung Cancer (SCLC). 184 SCLC patients' primary tumour samples were analyzed for ERCCI, BRCA1, ATP7B, PKM2 TOPOI, TOPOIIA, TOPOIIB and C-MYC mRNA expression. All patients were treated with cisplatin-etoposide. The patients' median age was 63 years and 120 (65%) had extended stage, 75 (41%) had increased LDH serum levels and 131 (71%) an ECOG performance status was 0-1. Patients with limited stage, whose tumours expressed high ERCC1 (p=0.028), PKM2 (p=0.046), TOPOI (p=0.008), TOPOIIA (p=0.002) and TOPOIIB (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0074611