Anthropometric measures and physical activity and the risk of lung cancer in never-smokers: a prospective cohort study

Anthropometric measures and physical activity and the risk of lung cancer in never-smokers: a prospective cohort study

Worldwide, lung cancer in never-smokers is ranked the seventh most common cause of cancer death; however, the etiology of lung cancer in never-smokers is unclear. We investigated associations for body mass index (BMI) at various ages, waist circumference, hip circumference, and physical activity wit...

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Veröffentlicht in:PloS one 2013-08, Vol.8 (8), p.e70672-e70672
Hauptverfasser: Lam, Tram Kim, Moore, Steve C, Brinton, Louise A, Smith, Llewellyn, Hollenbeck, Albert R, Gierach, Gretchen L, Freedman, Neal D
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - epidemiology
Adenocarcinoma - etiology
Aged
Anthropometry
Biology
Body mass
Body Mass Index
Body measurements
Body size
Body weight
Cancer
Cancer research
Cohort analysis
Confidence intervals
Development and progression
Epidemiology
Etiology
Exercise
Female
Gene expression
Genetics
Hazards
Health aspects
Health risk assessment
Health risks
Hip
Humans
Incidence
Lung cancer
Lung diseases
Lung Neoplasms - epidemiology
Lung Neoplasms - etiology
Male
Medicine
Mens health
Middle Aged
Mortality
Obesity
Overweight
Overweight - complications
Physical activity
Physical fitness
Proportional Hazards Models
Prospective Studies
Questionnaires
Risk
Risk Factors
Smokers
Smoking
Statistical models
Studies
Surveys and Questionnaires
Television
Television viewers
Waist Circumference
Womens health
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Zusammenfassung:Worldwide, lung cancer in never-smokers is ranked the seventh most common cause of cancer death; however, the etiology of lung cancer in never-smokers is unclear. We investigated associations for body mass index (BMI) at various ages, waist circumference, hip circumference, and physical activity with lung cancer in 158,415 never-smokers of the NIH-AARP Diet and Health Study. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were estimated from Cox proportional hazards models. Over 11 years of follow-up, 532 lung cancer cases occurred. The risk estimate for obese (BMI ≥ 30 kg/m(2)) participants at baseline was 1.21 (95%CI = 0.95-1.53) relative to those with a normal BMI between 18.5 ≤ BMI
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0070672