Cold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver

Cold exposure imposes a metabolic challenge to mammals that is met by a coordinated response in different tissues to prevent hypothermia. This study reports a transcriptomic analysis in brown adipose tissue (BAT), white adipose (WAT) and liver of mice in response to 24 h cold exposure at 8°C. Expres...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e68933-e68933
Hauptverfasser:	Shore, Andrew M, Karamitri, Angeliki, Kemp, Paul, Speakman, John R, Graham, Neil S, Lomax, Michael A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - metabolism Adipose Tissue, White - metabolism Animal tissues Animals Apolipoproteins Biology Body fat Cellular manufacture Cold Cold Temperature Cytochrome Cytochrome P450 Diabetes DNA binding proteins Exposure Female Gene expression Gene Expression Profiling Gene regulation Genes Genetic research Hypothermia Insulin Lipid metabolism Liver Liver - metabolism Metabolism Mice Mice, Inbred C57BL Organ Specificity Oxidoreductase Physiological aspects Principal components analysis Protease inhibitors Proteases Proteinase inhibitors Real time Thermogenesis Thyroid gland Time Factors Transcription factors
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Zusammenfassung:	Cold exposure imposes a metabolic challenge to mammals that is met by a coordinated response in different tissues to prevent hypothermia. This study reports a transcriptomic analysis in brown adipose tissue (BAT), white adipose (WAT) and liver of mice in response to 24 h cold exposure at 8°C. Expression of 1895 genes were significantly (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0068933