Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis

MicroRNAs (miRNAs) are present in human plasma and known as a non-invasive biomarker for cancer detection. Our study was designed to identify plasma miRNAs specific for rheumatoid arthritis (RA) by a comprehensive array approach. We performed a systematic, array-based miRNA analysis on plasma sample...

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Veröffentlicht in:	PloS one 2013-07, Vol.8 (7), p.e69118
Hauptverfasser:	Murata, Koichi, Furu, Moritoshi, Yoshitomi, Hiroyuki, Ishikawa, Masahiro, Shibuya, Hideyuki, Hashimoto, Motomu, Imura, Yoshitaka, Fujii, Takao, Ito, Hiromu, Mimori, Tsuneyo, Matsuda, Shuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Area Under Curve Arthritis Arthritis, Rheumatoid - blood Autoimmune diseases Biocompatibility Biology Biomarkers Biomarkers - blood Biomedical materials Blood plasma Breast cancer Cancer Cancer therapies Change detection Chronic conditions Citrulline Diagnostic systems Disease Humans Immunology Logistic Models Lupus Mathematics Medical diagnosis Medicine MicroRNA MicroRNAs MicroRNAs - blood miRNA Osteoarthritis Patients Plasma levels Real-Time Polymerase Chain Reaction Regression analysis Rheumatic diseases Rheumatoid arthritis Rheumatoid factor Rheumatology Ribonucleic acid RNA ROC Curve Somatotropin Statistical analysis Surgery Systemic lupus erythematosus University graduates
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Zusammenfassung:	MicroRNAs (miRNAs) are present in human plasma and known as a non-invasive biomarker for cancer detection. Our study was designed to identify plasma miRNAs specific for rheumatoid arthritis (RA) by a comprehensive array approach. We performed a systematic, array-based miRNA analysis on plasma samples from three RA patients and three healthy controls (HCs). Plasma miRNAs with more than four times change or with significant (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0069118