Effect of renal sympathetic denervation on atrial substrate remodeling in ambulatory canines with prolonged atrial pacing

We have previously demonstrated that catheter-based renal sympathetic denervation (RSD) could suppress atrial fibrillation (AF) in canines with short-time rapid right atrial pacing (RAP). However, the role of renal denervation on atrial remodeling is unclear. The aim of the present study was to expl...

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Veröffentlicht in:PloS one 2013-05, Vol.8 (5), p.e64611-e64611
Hauptverfasser: Wang, Xule, Zhao, Qingyan, Huang, He, Tang, Yanhong, Xiao, Jinping, Dai, Zixuan, Yu, Shengbo, Huang, Congxin
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Sprache:eng
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Zusammenfassung:We have previously demonstrated that catheter-based renal sympathetic denervation (RSD) could suppress atrial fibrillation (AF) in canines with short-time rapid right atrial pacing (RAP). However, the role of renal denervation on atrial remodeling is unclear. The aim of the present study was to explore the long-term effect of RSD on the atrial remodeling during prolonged RAP. Twenty mongrel dogs were implanted with a high-frequency cardiac pacemaker with a transvenous lead inserted into the right atrial appendage. The dogs were divided into three groups: a sham-operated group (n = 6), the chronic RAP (CRAP) group (n = 7), and the CRAP+RSD group (n = 7). In the CRAP+RSD group, a pacemaker was implanted 6 weeks after RSD was performed bilaterally for recovery. RAP was maintained for 5 weeks in CRAP group and CRAP+RSD group. The plasma levels of Angiotensin II and aldosterone were significantly increased in CRAP group compared with sham-operated group, but the increasing trend was inhibited in CRAP+RSD group compared with CRAP group (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0064611