Recurrent pregnancy loss in polycystic ovary syndrome: role of hyperhomocysteinemia and insulin resistance

Recurrent pregnancy loss in polycystic ovary syndrome: role of hyperhomocysteinemia and insulin resistance

Recurrent pregnancy loss (RPL) in polycystic ovary syndrome (PCOS), which occurs in ∼50% of total pregnancies is a frequent obstetric complication. Among the several hypotheses, insulin resistance (IR), obesity and hyperhomocysteinemia (HHcy) play significant role/s in RPL. This study was conducted...

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Veröffentlicht in:PloS one 2013-05, Vol.8 (5), p.e64446-e64446
Hauptverfasser: Chakraborty, Pratip, Goswami, S K, Rajani, Shweta, Sharma, Sunita, Kabir, Syed N, Chakravarty, Baidyanath, Jana, Kuladip
Format: Artikel
Sprache:eng
Schlagworte:
Abortion
Abortion, Habitual - etiology
Adult
Control programs
Female
Health risk assessment
Homocysteine
Humans
Hyperhomocysteinemia
Hyperhomocysteinemia - complications
Hyperhomocysteinemia - metabolism
Incidence
Infertility
Insulin
Insulin Resistance
Medicine
Miscarriage
Obesity
Polycystic ovary syndrome
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - metabolism
Pregnancy
Pregnant women
Prognosis
Retrospective Studies
Risk Factors
ROC Curve
Statistical analysis
Type 2 diabetes
Young Adult
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Zusammenfassung:Recurrent pregnancy loss (RPL) in polycystic ovary syndrome (PCOS), which occurs in ∼50% of total pregnancies is a frequent obstetric complication. Among the several hypotheses, insulin resistance (IR), obesity and hyperhomocysteinemia (HHcy) play significant role/s in RPL. This study was conducted to assess the link between elevated levels of homocysteine and IR in PCOS-associated women with RPL in Kolkata, India. A retrospective study was conducted of one hundred and twenty six PCOS women (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0064446