Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigation
Clinical symptoms and neuropsychological deficits are longitudinally associated with functional outcome in chronic psychiatric cohorts. The current study extended these findings to young and early-course psychiatric outpatients, with the aim of identifying cognitive markers that predict later socio-...
Gespeichert in:
Veröffentlicht in: | PloS one 2013-03, Vol.8 (3), p.e58176-e58176 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | e58176 |
---|---|
container_issue | 3 |
container_start_page | e58176 |
container_title | PloS one |
container_volume | 8 |
creator | Lee, Rico S C Hermens, Daniel F Redoblado-Hodge, M Antoinette Naismith, Sharon L Porter, Melanie A Kaur, Manreena White, Django Scott, Elizabeth M Hickie, Ian B |
description | Clinical symptoms and neuropsychological deficits are longitudinally associated with functional outcome in chronic psychiatric cohorts. The current study extended these findings to young and early-course psychiatric outpatients, with the aim of identifying cognitive markers that predict later socio-occupational functioning.
At baseline, 183 young psychiatric outpatients were assessed. Ninety-three returned for follow-up (M = 21.6 years old; SD = 4.5) with an average re-assessment interval of 21.6 months (SD = 7.0), and primary diagnoses of major depressive disorder (n = 34), bipolar disorder (n = 29), or psychosis (n = 30). The primary outcome measure was cross-validated with various other functional measures and structural equation modelling was used to map out the interrelationships between predictors and later functional outcome.
Good socio-occupational functioning at follow-up was associated with better quality of life, less disability, current employment and being in a romantic relationship. The final structural equation model explained 47.5% of the variability in functional outcome at follow-up, with baseline neuropsychological functioning (a composite of memory, working memory and attentional switching) the best independent predictor of later functional outcome. Notably, depressive and negative symptoms were only associated with functioning cross-sectionally. Diagnosis at follow-up was not associated with functional outcome.
Neuropsychological functioning was the single best predictor of later socio-occupational outcome among young psychiatric outpatients. Therefore, framing psychiatric disorders along a neuropsychological continuum is likely to be more useful in predicting functional trajectory than traditional symptom-based classification systems. The current findings also have implications for early intervention utilising cognitive remediation approaches. |
doi_str_mv | 10.1371/journal.pone.0058176 |
format | Article |
fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1346597135</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478448868</galeid><doaj_id>oai_doaj_org_article_883a46034cee4a50bc877ff93c805f7e</doaj_id><sourcerecordid>A478448868</sourcerecordid><originalsourceid>FETCH-LOGICAL-c653t-9c16fa555d981fc27458a9c103c17d77d409010bd4d1b85fef92f4e78247a943</originalsourceid><addsrcrecordid>eNqNkl1rFDEUhgdRbK3-A9EBQfRi12TyOV4IpfixUCxo8TZkM8lsljTZTpLi_nszu9OyK154lUPynPfkvLxV9RKCOUQMfliHPHjp5pvg9RwAwiGjj6pT2KJmRhuAHh_UJ9WzGNcFQpzSp9VJgzBtG8pPq_Rd5yFs4latggu9VdLV0nd1DMqGWVAqb2SyoQyqTfZqLK3va-vrbcil2HVamQar6pDTCGuf4sda1i743qbc2bHZ-jsdk-13Ys-rJ0a6qF9M51l1_eXz9cW32eXV18XF-eVMUYLSrFWQGkkI6VoOjWoYJlyWS4AUZB1jHQYtgGDZ4Q4uOTHatI3BmvEGM9lidFa93stuXIhi8isKWJYnLYOIFGKxJ7og12Iz2Bs5bEWQVuwuwtALOSSrnBacI4kpQFhpjSUBS8UZM6ZFigNimC5an6ZpeXmjO1VsGKQ7Ej1-8XYl-nAnEOGEtagIvJsEhnCbi1vixkalnZNehzz-GxLaMMJoQd_8hf57u4nqZVnAehPKXDWKinPMOMacU16o90eUCj7p36mXOUax-Pnj_9mrX8fs2wN2paVLqxhcHgMQj0G8B9UQYhy0efAMAjFG_X45MUZdTFEvba8O_X5ous82-gMrKfx3</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1346597135</pqid></control><display><type>article</type><title>Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigation</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Lee, Rico S C ; Hermens, Daniel F ; Redoblado-Hodge, M Antoinette ; Naismith, Sharon L ; Porter, Melanie A ; Kaur, Manreena ; White, Django ; Scott, Elizabeth M ; Hickie, Ian B</creator><creatorcontrib>Lee, Rico S C ; Hermens, Daniel F ; Redoblado-Hodge, M Antoinette ; Naismith, Sharon L ; Porter, Melanie A ; Kaur, Manreena ; White, Django ; Scott, Elizabeth M ; Hickie, Ian B</creatorcontrib><description>Clinical symptoms and neuropsychological deficits are longitudinally associated with functional outcome in chronic psychiatric cohorts. The current study extended these findings to young and early-course psychiatric outpatients, with the aim of identifying cognitive markers that predict later socio-occupational functioning.
At baseline, 183 young psychiatric outpatients were assessed. Ninety-three returned for follow-up (M = 21.6 years old; SD = 4.5) with an average re-assessment interval of 21.6 months (SD = 7.0), and primary diagnoses of major depressive disorder (n = 34), bipolar disorder (n = 29), or psychosis (n = 30). The primary outcome measure was cross-validated with various other functional measures and structural equation modelling was used to map out the interrelationships between predictors and later functional outcome.
Good socio-occupational functioning at follow-up was associated with better quality of life, less disability, current employment and being in a romantic relationship. The final structural equation model explained 47.5% of the variability in functional outcome at follow-up, with baseline neuropsychological functioning (a composite of memory, working memory and attentional switching) the best independent predictor of later functional outcome. Notably, depressive and negative symptoms were only associated with functioning cross-sectionally. Diagnosis at follow-up was not associated with functional outcome.
Neuropsychological functioning was the single best predictor of later socio-occupational outcome among young psychiatric outpatients. Therefore, framing psychiatric disorders along a neuropsychological continuum is likely to be more useful in predicting functional trajectory than traditional symptom-based classification systems. The current findings also have implications for early intervention utilising cognitive remediation approaches.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0058176</identifier><identifier>PMID: 23469268</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Achievement tests ; Adolescent ; Adult ; Analysis ; Behavior disorders ; Biology ; Bipolar disorder ; Bipolar Disorder - physiopathology ; Bipolar Disorder - psychology ; Bipolar Disorder - therapy ; Brain research ; Care and treatment ; Classification systems ; Cognitive ability ; Cognitive Behavioral Therapy ; Cognitive therapy ; Depressive Disorder, Major - physiopathology ; Depressive Disorder, Major - psychology ; Depressive Disorder, Major - therapy ; Ethics ; Female ; Humans ; Investigations ; Longitudinal Studies ; Male ; Mathematical models ; Medical diagnosis ; Medicine ; Memory, Short-Term - drug effects ; Mental Competency - psychology ; Mental depression ; Mental disorders ; Mental health ; Models, Psychological ; Neuropsychological Tests ; Neuropsychology ; Outpatients ; Patient outcomes ; Prognosis ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology ; Psychosis ; Psychotic Disorders - physiopathology ; Psychotic Disorders - psychology ; Psychotic Disorders - therapy ; Psychotropic Drugs - therapeutic use ; Quality of Life ; Schizophrenia ; Short term memory ; Social and Behavioral Sciences ; Structure-function relationships ; Studies ; Treatment Outcome</subject><ispartof>PloS one, 2013-03, Vol.8 (3), p.e58176-e58176</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Lee et al 2013 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-9c16fa555d981fc27458a9c103c17d77d409010bd4d1b85fef92f4e78247a943</citedby><cites>FETCH-LOGICAL-c653t-9c16fa555d981fc27458a9c103c17d77d409010bd4d1b85fef92f4e78247a943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585793/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585793/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23469268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Rico S C</creatorcontrib><creatorcontrib>Hermens, Daniel F</creatorcontrib><creatorcontrib>Redoblado-Hodge, M Antoinette</creatorcontrib><creatorcontrib>Naismith, Sharon L</creatorcontrib><creatorcontrib>Porter, Melanie A</creatorcontrib><creatorcontrib>Kaur, Manreena</creatorcontrib><creatorcontrib>White, Django</creatorcontrib><creatorcontrib>Scott, Elizabeth M</creatorcontrib><creatorcontrib>Hickie, Ian B</creatorcontrib><title>Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Clinical symptoms and neuropsychological deficits are longitudinally associated with functional outcome in chronic psychiatric cohorts. The current study extended these findings to young and early-course psychiatric outpatients, with the aim of identifying cognitive markers that predict later socio-occupational functioning.
At baseline, 183 young psychiatric outpatients were assessed. Ninety-three returned for follow-up (M = 21.6 years old; SD = 4.5) with an average re-assessment interval of 21.6 months (SD = 7.0), and primary diagnoses of major depressive disorder (n = 34), bipolar disorder (n = 29), or psychosis (n = 30). The primary outcome measure was cross-validated with various other functional measures and structural equation modelling was used to map out the interrelationships between predictors and later functional outcome.
Good socio-occupational functioning at follow-up was associated with better quality of life, less disability, current employment and being in a romantic relationship. The final structural equation model explained 47.5% of the variability in functional outcome at follow-up, with baseline neuropsychological functioning (a composite of memory, working memory and attentional switching) the best independent predictor of later functional outcome. Notably, depressive and negative symptoms were only associated with functioning cross-sectionally. Diagnosis at follow-up was not associated with functional outcome.
Neuropsychological functioning was the single best predictor of later socio-occupational outcome among young psychiatric outpatients. Therefore, framing psychiatric disorders along a neuropsychological continuum is likely to be more useful in predicting functional trajectory than traditional symptom-based classification systems. The current findings also have implications for early intervention utilising cognitive remediation approaches.</description><subject>Achievement tests</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Behavior disorders</subject><subject>Biology</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Bipolar Disorder - psychology</subject><subject>Bipolar Disorder - therapy</subject><subject>Brain research</subject><subject>Care and treatment</subject><subject>Classification systems</subject><subject>Cognitive ability</subject><subject>Cognitive Behavioral Therapy</subject><subject>Cognitive therapy</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Depressive Disorder, Major - psychology</subject><subject>Depressive Disorder, Major - therapy</subject><subject>Ethics</subject><subject>Female</subject><subject>Humans</subject><subject>Investigations</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Memory, Short-Term - drug effects</subject><subject>Mental Competency - psychology</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Models, Psychological</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Outpatients</subject><subject>Patient outcomes</subject><subject>Prognosis</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology</subject><subject>Psychosis</subject><subject>Psychotic Disorders - physiopathology</subject><subject>Psychotic Disorders - psychology</subject><subject>Psychotic Disorders - therapy</subject><subject>Psychotropic Drugs - therapeutic use</subject><subject>Quality of Life</subject><subject>Schizophrenia</subject><subject>Short term memory</subject><subject>Social and Behavioral Sciences</subject><subject>Structure-function relationships</subject><subject>Studies</subject><subject>Treatment Outcome</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1rFDEUhgdRbK3-A9EBQfRi12TyOV4IpfixUCxo8TZkM8lsljTZTpLi_nszu9OyK154lUPynPfkvLxV9RKCOUQMfliHPHjp5pvg9RwAwiGjj6pT2KJmRhuAHh_UJ9WzGNcFQpzSp9VJgzBtG8pPq_Rd5yFs4latggu9VdLV0nd1DMqGWVAqb2SyoQyqTfZqLK3va-vrbcil2HVamQar6pDTCGuf4sda1i743qbc2bHZ-jsdk-13Ys-rJ0a6qF9M51l1_eXz9cW32eXV18XF-eVMUYLSrFWQGkkI6VoOjWoYJlyWS4AUZB1jHQYtgGDZ4Q4uOTHatI3BmvEGM9lidFa93stuXIhi8isKWJYnLYOIFGKxJ7og12Iz2Bs5bEWQVuwuwtALOSSrnBacI4kpQFhpjSUBS8UZM6ZFigNimC5an6ZpeXmjO1VsGKQ7Ej1-8XYl-nAnEOGEtagIvJsEhnCbi1vixkalnZNehzz-GxLaMMJoQd_8hf57u4nqZVnAehPKXDWKinPMOMacU16o90eUCj7p36mXOUax-Pnj_9mrX8fs2wN2paVLqxhcHgMQj0G8B9UQYhy0efAMAjFG_X45MUZdTFEvba8O_X5ous82-gMrKfx3</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Lee, Rico S C</creator><creator>Hermens, Daniel F</creator><creator>Redoblado-Hodge, M Antoinette</creator><creator>Naismith, Sharon L</creator><creator>Porter, Melanie A</creator><creator>Kaur, Manreena</creator><creator>White, Django</creator><creator>Scott, Elizabeth M</creator><creator>Hickie, Ian B</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130301</creationdate><title>Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigation</title><author>Lee, Rico S C ; Hermens, Daniel F ; Redoblado-Hodge, M Antoinette ; Naismith, Sharon L ; Porter, Melanie A ; Kaur, Manreena ; White, Django ; Scott, Elizabeth M ; Hickie, Ian B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-9c16fa555d981fc27458a9c103c17d77d409010bd4d1b85fef92f4e78247a943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Achievement tests</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Behavior disorders</topic><topic>Biology</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Bipolar Disorder - psychology</topic><topic>Bipolar Disorder - therapy</topic><topic>Brain research</topic><topic>Care and treatment</topic><topic>Classification systems</topic><topic>Cognitive ability</topic><topic>Cognitive Behavioral Therapy</topic><topic>Cognitive therapy</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Depressive Disorder, Major - psychology</topic><topic>Depressive Disorder, Major - therapy</topic><topic>Ethics</topic><topic>Female</topic><topic>Humans</topic><topic>Investigations</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Memory, Short-Term - drug effects</topic><topic>Mental Competency - psychology</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Models, Psychological</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>Outpatients</topic><topic>Patient outcomes</topic><topic>Prognosis</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology</topic><topic>Psychosis</topic><topic>Psychotic Disorders - physiopathology</topic><topic>Psychotic Disorders - psychology</topic><topic>Psychotic Disorders - therapy</topic><topic>Psychotropic Drugs - therapeutic use</topic><topic>Quality of Life</topic><topic>Schizophrenia</topic><topic>Short term memory</topic><topic>Social and Behavioral Sciences</topic><topic>Structure-function relationships</topic><topic>Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Rico S C</creatorcontrib><creatorcontrib>Hermens, Daniel F</creatorcontrib><creatorcontrib>Redoblado-Hodge, M Antoinette</creatorcontrib><creatorcontrib>Naismith, Sharon L</creatorcontrib><creatorcontrib>Porter, Melanie A</creatorcontrib><creatorcontrib>Kaur, Manreena</creatorcontrib><creatorcontrib>White, Django</creatorcontrib><creatorcontrib>Scott, Elizabeth M</creatorcontrib><creatorcontrib>Hickie, Ian B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Rico S C</au><au>Hermens, Daniel F</au><au>Redoblado-Hodge, M Antoinette</au><au>Naismith, Sharon L</au><au>Porter, Melanie A</au><au>Kaur, Manreena</au><au>White, Django</au><au>Scott, Elizabeth M</au><au>Hickie, Ian B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>8</volume><issue>3</issue><spage>e58176</spage><epage>e58176</epage><pages>e58176-e58176</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Clinical symptoms and neuropsychological deficits are longitudinally associated with functional outcome in chronic psychiatric cohorts. The current study extended these findings to young and early-course psychiatric outpatients, with the aim of identifying cognitive markers that predict later socio-occupational functioning.
At baseline, 183 young psychiatric outpatients were assessed. Ninety-three returned for follow-up (M = 21.6 years old; SD = 4.5) with an average re-assessment interval of 21.6 months (SD = 7.0), and primary diagnoses of major depressive disorder (n = 34), bipolar disorder (n = 29), or psychosis (n = 30). The primary outcome measure was cross-validated with various other functional measures and structural equation modelling was used to map out the interrelationships between predictors and later functional outcome.
Good socio-occupational functioning at follow-up was associated with better quality of life, less disability, current employment and being in a romantic relationship. The final structural equation model explained 47.5% of the variability in functional outcome at follow-up, with baseline neuropsychological functioning (a composite of memory, working memory and attentional switching) the best independent predictor of later functional outcome. Notably, depressive and negative symptoms were only associated with functioning cross-sectionally. Diagnosis at follow-up was not associated with functional outcome.
Neuropsychological functioning was the single best predictor of later socio-occupational outcome among young psychiatric outpatients. Therefore, framing psychiatric disorders along a neuropsychological continuum is likely to be more useful in predicting functional trajectory than traditional symptom-based classification systems. The current findings also have implications for early intervention utilising cognitive remediation approaches.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23469268</pmid><doi>10.1371/journal.pone.0058176</doi><tpages>e58176</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2013-03, Vol.8 (3), p.e58176-e58176 |
issn | 1932-6203 1932-6203 |
language | eng |
recordid | cdi_plos_journals_1346597135 |
source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
subjects | Achievement tests Adolescent Adult Analysis Behavior disorders Biology Bipolar disorder Bipolar Disorder - physiopathology Bipolar Disorder - psychology Bipolar Disorder - therapy Brain research Care and treatment Classification systems Cognitive ability Cognitive Behavioral Therapy Cognitive therapy Depressive Disorder, Major - physiopathology Depressive Disorder, Major - psychology Depressive Disorder, Major - therapy Ethics Female Humans Investigations Longitudinal Studies Male Mathematical models Medical diagnosis Medicine Memory, Short-Term - drug effects Mental Competency - psychology Mental depression Mental disorders Mental health Models, Psychological Neuropsychological Tests Neuropsychology Outpatients Patient outcomes Prognosis Psychiatric Status Rating Scales Psychiatry Psychology Psychosis Psychotic Disorders - physiopathology Psychotic Disorders - psychology Psychotic Disorders - therapy Psychotropic Drugs - therapeutic use Quality of Life Schizophrenia Short term memory Social and Behavioral Sciences Structure-function relationships Studies Treatment Outcome |
title | Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigation |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T04%3A48%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuropsychological%20and%20socio-occupational%20functioning%20in%20young%20psychiatric%20outpatients:%20a%20longitudinal%20investigation&rft.jtitle=PloS%20one&rft.au=Lee,%20Rico%20S%20C&rft.date=2013-03-01&rft.volume=8&rft.issue=3&rft.spage=e58176&rft.epage=e58176&rft.pages=e58176-e58176&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0058176&rft_dat=%3Cgale_plos_%3EA478448868%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1346597135&rft_id=info:pmid/23469268&rft_galeid=A478448868&rft_doaj_id=oai_doaj_org_article_883a46034cee4a50bc877ff93c805f7e&rfr_iscdi=true |