HER2 amplification and clinicopathological characteristics in a large Asian cohort of rare mucinous ovarian cancer

Mucinous epithelial ovarian cancer has a poor prognosis in the advanced stages and responds poorly to conventional chemotherapy. We aim to elucidate the clinicopathological factors and incidence of HER2 expression of this cancer in a large Asian retrospective cohort from Singapore. Of a total of 133...

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Veröffentlicht in:PloS one 2013-04, Vol.8 (4), p.e61565
Hauptverfasser: Chay, Wen-Yee, Chew, Sung-Hock, Ong, Whee-Sze, Busmanis, Inny, Li, Xinyun, Thung, Sharyl, Ngo, Lynette, Lim, Sheow-Lei, Lim, Yong-Kuei, Chia, Yin-Nin, Koh, Elisa, Pang, Cindy, Soh, Lay-Tin, Wang, Jin, Ho, Tew-Hong, Tay, Sun-Kuie, Lim-Tan, Soo-Kim, Lim, Kiat-Hon, Chia, John Whay-Kuang, Goh, Liang-Kee
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container_issue 4
container_start_page e61565
container_title PloS one
container_volume 8
creator Chay, Wen-Yee
Chew, Sung-Hock
Ong, Whee-Sze
Busmanis, Inny
Li, Xinyun
Thung, Sharyl
Ngo, Lynette
Lim, Sheow-Lei
Lim, Yong-Kuei
Chia, Yin-Nin
Koh, Elisa
Pang, Cindy
Soh, Lay-Tin
Wang, Jin
Ho, Tew-Hong
Tay, Sun-Kuie
Lim-Tan, Soo-Kim
Lim, Kiat-Hon
Chia, John Whay-Kuang
Goh, Liang-Kee
description Mucinous epithelial ovarian cancer has a poor prognosis in the advanced stages and responds poorly to conventional chemotherapy. We aim to elucidate the clinicopathological factors and incidence of HER2 expression of this cancer in a large Asian retrospective cohort from Singapore. Of a total of 133 cases, the median age at diagnosis was 48.3 years (range, 15.8-89.0 years), comparatively younger than western cohorts. Most were Chinese (71%), followed by Malays (16%), others (9.0%), and Indians (5%). 24% were noted to have a significant family history of malignancy of which breast and gastrointestinal cancers the most prominent. Majority of the patients (80%) had stage I disease at diagnosis. Information on HER2 status was available in 113 cases (85%). Of these, 31 cases (27.4%) were HER2+, higher than 18.8% reported in western population. HER2 positivity appeared to be lower among Chinese and higher among Malays patients (p = 0.052). With the current standard of care, there was no discernible impact of HER2 status on overall survival. (HR = 1.79; 95% CI, 0.66-4.85; p = 0.249). On the other hand, positive family history of cancer, presence of lymphovascular invasion, and ovarian surface involvements were significantly associated with inferior overall survival on univariate and continued to be statistically significant after adjustment for stage. While these clinical factors identify high risk patients, it is promising that the finding of a high incidence of HER2 in our Asian population may allow development of a HER2 targeted therapy to improve the management of mucinous ovarian cancers.
doi_str_mv 10.1371/journal.pone.0061565
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We aim to elucidate the clinicopathological factors and incidence of HER2 expression of this cancer in a large Asian retrospective cohort from Singapore. Of a total of 133 cases, the median age at diagnosis was 48.3 years (range, 15.8-89.0 years), comparatively younger than western cohorts. Most were Chinese (71%), followed by Malays (16%), others (9.0%), and Indians (5%). 24% were noted to have a significant family history of malignancy of which breast and gastrointestinal cancers the most prominent. Majority of the patients (80%) had stage I disease at diagnosis. Information on HER2 status was available in 113 cases (85%). Of these, 31 cases (27.4%) were HER2+, higher than 18.8% reported in western population. HER2 positivity appeared to be lower among Chinese and higher among Malays patients (p = 0.052). With the current standard of care, there was no discernible impact of HER2 status on overall survival. (HR = 1.79; 95% CI, 0.66-4.85; p = 0.249). On the other hand, positive family history of cancer, presence of lymphovascular invasion, and ovarian surface involvements were significantly associated with inferior overall survival on univariate and continued to be statistically significant after adjustment for stage. While these clinical factors identify high risk patients, it is promising that the finding of a high incidence of HER2 in our Asian population may allow development of a HER2 targeted therapy to improve the management of mucinous ovarian cancers.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0061565</identifier><identifier>PMID: 23620766</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenocarcinoma, Mucinous - genetics ; Adenocarcinoma, Mucinous - pathology ; Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group - genetics ; Breast cancer ; Cancer ; Cancer therapies ; Chemotherapy ; Children &amp; youth ; Cohort Studies ; Diagnosis ; Disease-Free Survival ; ErbB-2 protein ; Family ; Family medical history ; Female ; Gastric cancer ; Gene Amplification ; Genetics ; Gynecology ; Histopathology ; Humans ; Incidence ; Lymphatic system ; Malignancy ; Medical diagnosis ; Medicine ; Metastasis ; Middle Aged ; Obstetrics ; Oncology ; Ovarian cancer ; Ovarian carcinoma ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - pathology ; Pathology ; Patients ; Prognosis ; Receptor, ErbB-2 - genetics ; Risk factors ; Singapore ; Statistical analysis ; Stomach cancer ; Studies ; Survival ; Tumors ; Womens health ; Young Adult</subject><ispartof>PloS one, 2013-04, Vol.8 (4), p.e61565</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Chay et al. 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We aim to elucidate the clinicopathological factors and incidence of HER2 expression of this cancer in a large Asian retrospective cohort from Singapore. Of a total of 133 cases, the median age at diagnosis was 48.3 years (range, 15.8-89.0 years), comparatively younger than western cohorts. Most were Chinese (71%), followed by Malays (16%), others (9.0%), and Indians (5%). 24% were noted to have a significant family history of malignancy of which breast and gastrointestinal cancers the most prominent. Majority of the patients (80%) had stage I disease at diagnosis. Information on HER2 status was available in 113 cases (85%). Of these, 31 cases (27.4%) were HER2+, higher than 18.8% reported in western population. HER2 positivity appeared to be lower among Chinese and higher among Malays patients (p = 0.052). With the current standard of care, there was no discernible impact of HER2 status on overall survival. (HR = 1.79; 95% CI, 0.66-4.85; p = 0.249). On the other hand, positive family history of cancer, presence of lymphovascular invasion, and ovarian surface involvements were significantly associated with inferior overall survival on univariate and continued to be statistically significant after adjustment for stage. While these clinical factors identify high risk patients, it is promising that the finding of a high incidence of HER2 in our Asian population may allow development of a HER2 targeted therapy to improve the management of mucinous ovarian cancers.</description><subject>Adenocarcinoma, Mucinous - genetics</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Children &amp; youth</subject><subject>Cohort Studies</subject><subject>Diagnosis</subject><subject>Disease-Free Survival</subject><subject>ErbB-2 protein</subject><subject>Family</subject><subject>Family medical history</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gene Amplification</subject><subject>Genetics</subject><subject>Gynecology</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lymphatic system</subject><subject>Malignancy</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Obstetrics</subject><subject>Oncology</subject><subject>Ovarian cancer</subject><subject>Ovarian carcinoma</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Pathology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Risk factors</subject><subject>Singapore</subject><subject>Statistical analysis</subject><subject>Stomach cancer</subject><subject>Studies</subject><subject>Survival</subject><subject>Tumors</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkm-L1DAQxoso3rn6DUQLguCLXZumSds3wnKc3sLBwfnnbZhOkzZLNlmT9tBvb_a2d2xBQfKiYeY3TyczT5K8JtmK0JJ83LrRWzCrvbNylWWcMM6eJOekpvmS5xl9enI_S16EsM0yRivOnydnOY3RkvPzxF9d3uYp7PZGK40waGdTsG2KRluNbg9D74zrYsqk2IMHHKTXYdAYUh3R1IDvZLoOGmyKrnd-SJ1KPXiZ7kbU1o0hdXfg7_NgUfqXyTMFJshX03eRfP98-e3ianl982Vzsb5eIq_zYckVyYAhpwobXtbI8oxhVfPYNy0bJikvKsooldAwWpMG24ooVascGqIKZHSRvD3q7o0LYhpXEIQWtCrKipBIbI5E62Ar9l7vwP8WDrS4DzjfCfDxqUYKRCxZxXLZNm0BqqoalqFqyoqTjNcVRq1P09_GZidblHbwYGai84zVvejcnaCckjxuapG8mwS8-znKMPyj5YnqIHalrXJRDHc6oFhHIidxxYenr_5CxdPKXdyqlUrH-Kzgw6wgMoP8NXQwhiA2X2__n735MWffn7C9BDP0wZnx4LMwB4sjiN6F4KV6nBzJxMHvD9MQB7-Lye-x7M3p1B-LHgxO_wCrXPwk</recordid><startdate>20130419</startdate><enddate>20130419</enddate><creator>Chay, Wen-Yee</creator><creator>Chew, Sung-Hock</creator><creator>Ong, Whee-Sze</creator><creator>Busmanis, Inny</creator><creator>Li, Xinyun</creator><creator>Thung, Sharyl</creator><creator>Ngo, Lynette</creator><creator>Lim, Sheow-Lei</creator><creator>Lim, Yong-Kuei</creator><creator>Chia, Yin-Nin</creator><creator>Koh, Elisa</creator><creator>Pang, Cindy</creator><creator>Soh, Lay-Tin</creator><creator>Wang, Jin</creator><creator>Ho, Tew-Hong</creator><creator>Tay, Sun-Kuie</creator><creator>Lim-Tan, Soo-Kim</creator><creator>Lim, Kiat-Hon</creator><creator>Chia, John Whay-Kuang</creator><creator>Goh, Liang-Kee</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130419</creationdate><title>HER2 amplification and clinicopathological characteristics in a large Asian cohort of rare mucinous ovarian cancer</title><author>Chay, Wen-Yee ; Chew, Sung-Hock ; Ong, Whee-Sze ; Busmanis, Inny ; Li, Xinyun ; Thung, Sharyl ; Ngo, Lynette ; Lim, Sheow-Lei ; Lim, Yong-Kuei ; Chia, Yin-Nin ; Koh, Elisa ; Pang, Cindy ; Soh, Lay-Tin ; Wang, Jin ; Ho, Tew-Hong ; Tay, Sun-Kuie ; Lim-Tan, Soo-Kim ; Lim, Kiat-Hon ; Chia, John Whay-Kuang ; Goh, Liang-Kee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6f10a5c63fcb679c5205c89607637b5e36483533eab5391bcd81ff9f2ab1f4c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma, Mucinous - genetics</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Children &amp; youth</topic><topic>Cohort Studies</topic><topic>Diagnosis</topic><topic>Disease-Free Survival</topic><topic>ErbB-2 protein</topic><topic>Family</topic><topic>Family medical history</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gene Amplification</topic><topic>Genetics</topic><topic>Gynecology</topic><topic>Histopathology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lymphatic system</topic><topic>Malignancy</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Obstetrics</topic><topic>Oncology</topic><topic>Ovarian cancer</topic><topic>Ovarian carcinoma</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Pathology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Receptor, ErbB-2 - genetics</topic><topic>Risk factors</topic><topic>Singapore</topic><topic>Statistical analysis</topic><topic>Stomach cancer</topic><topic>Studies</topic><topic>Survival</topic><topic>Tumors</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chay, Wen-Yee</creatorcontrib><creatorcontrib>Chew, Sung-Hock</creatorcontrib><creatorcontrib>Ong, Whee-Sze</creatorcontrib><creatorcontrib>Busmanis, Inny</creatorcontrib><creatorcontrib>Li, Xinyun</creatorcontrib><creatorcontrib>Thung, Sharyl</creatorcontrib><creatorcontrib>Ngo, Lynette</creatorcontrib><creatorcontrib>Lim, Sheow-Lei</creatorcontrib><creatorcontrib>Lim, Yong-Kuei</creatorcontrib><creatorcontrib>Chia, Yin-Nin</creatorcontrib><creatorcontrib>Koh, Elisa</creatorcontrib><creatorcontrib>Pang, Cindy</creatorcontrib><creatorcontrib>Soh, Lay-Tin</creatorcontrib><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Ho, Tew-Hong</creatorcontrib><creatorcontrib>Tay, Sun-Kuie</creatorcontrib><creatorcontrib>Lim-Tan, Soo-Kim</creatorcontrib><creatorcontrib>Lim, Kiat-Hon</creatorcontrib><creatorcontrib>Chia, John Whay-Kuang</creatorcontrib><creatorcontrib>Goh, Liang-Kee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health &amp; Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied &amp; Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chay, Wen-Yee</au><au>Chew, Sung-Hock</au><au>Ong, Whee-Sze</au><au>Busmanis, Inny</au><au>Li, Xinyun</au><au>Thung, Sharyl</au><au>Ngo, Lynette</au><au>Lim, Sheow-Lei</au><au>Lim, Yong-Kuei</au><au>Chia, Yin-Nin</au><au>Koh, Elisa</au><au>Pang, Cindy</au><au>Soh, Lay-Tin</au><au>Wang, Jin</au><au>Ho, Tew-Hong</au><au>Tay, Sun-Kuie</au><au>Lim-Tan, Soo-Kim</au><au>Lim, Kiat-Hon</au><au>Chia, John Whay-Kuang</au><au>Goh, Liang-Kee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HER2 amplification and clinicopathological characteristics in a large Asian cohort of rare mucinous ovarian cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-04-19</date><risdate>2013</risdate><volume>8</volume><issue>4</issue><spage>e61565</spage><pages>e61565-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Mucinous epithelial ovarian cancer has a poor prognosis in the advanced stages and responds poorly to conventional chemotherapy. We aim to elucidate the clinicopathological factors and incidence of HER2 expression of this cancer in a large Asian retrospective cohort from Singapore. Of a total of 133 cases, the median age at diagnosis was 48.3 years (range, 15.8-89.0 years), comparatively younger than western cohorts. Most were Chinese (71%), followed by Malays (16%), others (9.0%), and Indians (5%). 24% were noted to have a significant family history of malignancy of which breast and gastrointestinal cancers the most prominent. Majority of the patients (80%) had stage I disease at diagnosis. Information on HER2 status was available in 113 cases (85%). Of these, 31 cases (27.4%) were HER2+, higher than 18.8% reported in western population. HER2 positivity appeared to be lower among Chinese and higher among Malays patients (p = 0.052). With the current standard of care, there was no discernible impact of HER2 status on overall survival. (HR = 1.79; 95% CI, 0.66-4.85; p = 0.249). On the other hand, positive family history of cancer, presence of lymphovascular invasion, and ovarian surface involvements were significantly associated with inferior overall survival on univariate and continued to be statistically significant after adjustment for stage. While these clinical factors identify high risk patients, it is promising that the finding of a high incidence of HER2 in our Asian population may allow development of a HER2 targeted therapy to improve the management of mucinous ovarian cancers.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23620766</pmid><doi>10.1371/journal.pone.0061565</doi><tpages>e61565</tpages><oa>free_for_read</oa></addata></record>
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subjects Adenocarcinoma, Mucinous - genetics
Adenocarcinoma, Mucinous - pathology
Adolescent
Adult
Age
Aged
Aged, 80 and over
Asian Continental Ancestry Group - genetics
Breast cancer
Cancer
Cancer therapies
Chemotherapy
Children & youth
Cohort Studies
Diagnosis
Disease-Free Survival
ErbB-2 protein
Family
Family medical history
Female
Gastric cancer
Gene Amplification
Genetics
Gynecology
Histopathology
Humans
Incidence
Lymphatic system
Malignancy
Medical diagnosis
Medicine
Metastasis
Middle Aged
Obstetrics
Oncology
Ovarian cancer
Ovarian carcinoma
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Pathology
Patients
Prognosis
Receptor, ErbB-2 - genetics
Risk factors
Singapore
Statistical analysis
Stomach cancer
Studies
Survival
Tumors
Womens health
Young Adult
title HER2 amplification and clinicopathological characteristics in a large Asian cohort of rare mucinous ovarian cancer
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