Sirtuin1: a promising serum protein marker for early detection of Alzheimer's disease

Sirtuin1: a promising serum protein marker for early detection of Alzheimer's disease

Sirtuin (SIRT) pathway has a crucial role in Alzheimer's disease (AD). The present study evaluated the alterations in serum sirtuin1 (SIRT1) concentration in healthy individuals (young and old) and patients with AD and mild cognitive impairment (MCI). Blood samples were collected from 40 AD and...

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Veröffentlicht in:PloS one 2013-04, Vol.8 (4), p.e61560-e61560
Hauptverfasser: Kumar, Rahul, Chaterjee, Prasun, Sharma, Prakash K, Singh, Abhay K, Gupta, Abhishek, Gill, Kamaldeep, Tripathi, Manjari, Dey, Aparajit B, Dey, Sharmistha
Format: Artikel
Sprache:eng
Schlagworte:
Activities of daily living
Adults
Advertising executives
Aged
Aging
Alzheimer Disease - blood
Alzheimer Disease - diagnosis
Alzheimer's disease
Animal cognition
Biology
Biomarkers - blood
Biophysics
Biosensors
Blood proteins
Cognitive ability
Cognitive Dysfunction - blood
Cognitive Dysfunction - diagnosis
Comparative analysis
Dementia
Disease
Elderly
Enzyme-linked immunosorbent assay
Enzymes
Female
Geriatrics
Humans
Male
Medical research
Medicine
Middle Aged
Neurodegeneration
Neurodegenerative diseases
Neurology
Older people
Patients
Peptides
Proteins
Proteomics
SIRT1 protein
Sirtuin 1 - blood
Surface plasmon resonance
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Beschreibung
Zusammenfassung:Sirtuin (SIRT) pathway has a crucial role in Alzheimer's disease (AD). The present study evaluated the alterations in serum sirtuin1 (SIRT1) concentration in healthy individuals (young and old) and patients with AD and mild cognitive impairment (MCI). Blood samples were collected from 40 AD and 9 MCI patients as cases and 22 young healthy adults and 22 healthy elderly individuals as controls. Serum SIRT1 was estimated by Surface Plasmon Resonance (SPR), Western Blot and Enzyme Linked Immunosorbent Assay (ELISA). A significant (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0061560