Hsa-miR-499 rs3746444 polymorphism contributes to cancer risk: a meta-analysis of 12 studies

Single nucleotide polymorphisms (SNPs) occurred in pre-microRNAs or targets of microRNAs (miRs) may contribute to cancer risks. Since 2007, many studies have investigated the association between common SNPs located on hsa-miR-499 (rs3746444) and cancer risks; however, the results were inconclusive....

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e50887-e50887
Hauptverfasser:	Qiu, Man-Tang, Hu, Jing-Wen, Ding, Xiang-Xiang, Yang, Xin, Zhang, Zhi, Yin, Rong, Xu, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Asian Continental Ancestry Group - genetics Biology Bladder cancer Breast cancer Cancer Cancer prevention Cancer research Clinical trials Confidence intervals Equilibrium Ethnicity Gastric cancer Gene polymorphism Genes Genetic aspects Genetic Predisposition to Disease Genotype Genotypes Health aspects Health risk assessment Health risks Health savings accounts Humans Liver cancer Medical ethics Medicine Meta-analysis MicroRNA MicroRNAs MicroRNAs - genetics Minority & ethnic groups miRNA Neoplasms - genetics Polymorphism Polymorphism, Single Nucleotide Population Quality Regression analysis Risk Risk analysis Risk factors Risk reduction Single nucleotide polymorphisms Single-nucleotide polymorphism Squamous cell carcinoma Statistical analysis Stomach cancer Studies Surgery Thoracic surgery
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Zusammenfassung:	Single nucleotide polymorphisms (SNPs) occurred in pre-microRNAs or targets of microRNAs (miRs) may contribute to cancer risks. Since 2007, many studies have investigated the association between common SNPs located on hsa-miR-499 (rs3746444) and cancer risks; however, the results were inconclusive. We conducted a meta-analysis of 12 studies that included 5765 cases and 7076 controls to identify the strength of association. Odds ratio (OR) and 95% confidence intervals (95% CI) were used to assess the strength of association. Overall, individuals with the variant AG (OR = 1.215, 95% CI: 1.027, 1.437; P(heterogeneity)
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0050887