Molecular characterization of chronic lymphocytic leukemia patients with a high number of losses in 13q14

Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48485
Hauptverfasser:	Rodríguez, Ana Eugenia, Hernández, Jose Ángel, Benito, Rocío, Gutiérrez, Norma C, García, Juan Luis, Hernández-Sánchez, María, Risueño, Alberto, Sarasquete, M Eugenia, Fermiñán, Encarna, Fisac, Rosa, de Coca, Alfonso García, Martín-Núñez, Guillermo, de Las Heras, Natalia, Recio, Isabel, Gutiérrez, Oliver, De Las Rivas, Javier, González, Marcos, Hernández-Rivas, Jesús M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Adult Aged Aged, 80 and over Alleles Analysis Apoptosis B cells Biology Case-Control Studies Cell survival Chromosome 13 Chromosome Deletion Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 17 Chronic lymphocytic leukemia Clonal deletion Cluster Analysis Deregulation Female Flow cytometry Gene expression Gene Expression Profiling Gene Expression Regulation, Leukemic Genes Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Kinases Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Lymphatic leukemia Lymphocyte receptors Male Medical prognosis Medicine MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Mutation NF-κB protein Patients Ribonucleic acid RNA Signal Transduction Signaling Studies
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Zusammenfassung:	Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors. Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (>80%) showed a different level of gene expression as compared to patients with lower percentages (
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0048485