Heart failure induces significant changes in nuclear pore complex of human cardiomyocytes

The objectives of this study were to analyse the effect of heart failure (HF) on several proteins of nuclear pore complex (NPC) and their relationship with the human ventricular function. A total of 88 human heart samples from ischemic (ICM, n = 52) and dilated (DCM, n = 36) patients undergoing hear...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48957-e48957
Hauptverfasser:	Tarazón, Estefanía, Rivera, Miguel, Roselló-Lletí, Esther, Molina-Navarro, Maria Micaela, Sánchez-Lázaro, Ignacio José, España, Francisco, Montero, José Anastasio, Lago, Francisca, González-Juanatey, José Ramón, Portolés, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcohol Biology Biomedical research Cardiology Cardiomyocytes Cardiomyopathy Ethics Etiology Female Fluorescence Heart Heart diseases Heart failure Heart Failure - etiology Heart Failure - metabolism Heart transplantation Heart Ventricles - metabolism Heart Ventricles - physiopathology Hospitals Humans Immunocytochemistry Ischemia Male Medicine Middle Aged Monoclonal antibodies Mutation Myocytes, Cardiac - metabolism Nuclear Pore Complex Proteins - metabolism Nuclear Proteins - metabolism Nuclei Nuclei (cytology) Nucleoporins Protein Transport Proteins Transplants & implants Values Ventricle
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Zusammenfassung:	The objectives of this study were to analyse the effect of heart failure (HF) on several proteins of nuclear pore complex (NPC) and their relationship with the human ventricular function. A total of 88 human heart samples from ischemic (ICM, n = 52) and dilated (DCM, n = 36) patients undergoing heart transplant and control donors (CNT, n = 9) were analyzed by Western blot. Subcellular distribution of nucleoporins was analysed by fluorescence and immunocytochemistry. When we compared protein levels according to etiology, ICM showed significant higher levels of NDC1 (65%, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0048957