Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene

Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with mouse AHR and human asthma-related phenotypes. Our goal was to identify asthm...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e56179-e56179
Hauptverfasser:	Himes, Blanca E, Sheppard, Keith, Berndt, Annerose, Leme, Adriana S, Myers, Rachel A, Gignoux, Christopher R, Levin, Albert M, Gauderman, W James, Yang, James J, Mathias, Rasika A, Romieu, Isabelle, Torgerson, Dara G, Roth, Lindsey A, Huntsman, Scott, Eng, Celeste, Klanderman, Barbara, Ziniti, John, Senter-Sylvia, Jody, Szefler, Stanley J, Lemanske, Jr, Robert F, Zeiger, Robert S, Strunk, Robert C, Martinez, Fernando D, Boushey, Homer, Chinchilli, Vernon M, Israel, Elliot, Mauger, David, Koppelman, Gerard H, Postma, Dirkje S, Nieuwenhuis, Maartje A E, Vonk, Judith M, Lima, John J, Irvin, Charles G, Peters, Stephen P, Kubo, Michiaki, Tamari, Mayumi, Nakamura, Yusuke, Litonjua, Augusto A, Tantisira, Kelan G, Raby, Benjamin A, Bleecker, Eugene R, Meyers, Deborah A, London, Stephanie J, Barnes, Kathleen C, Gilliland, Frank D, Williams, L Keoki, Burchard, Esteban G, Nicolae, Dan L, Ober, Carole, DeMeo, Dawn L, Silverman, Edwin K, Paigen, Beverly, Churchill, Gary, Shapiro, Steve D, Weiss, Scott T
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Asthma Asthma - genetics Base Sequence Biology Cardiovascular disease Consortia Critical care Diacylglycerol Female Females Genes Genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics Genotype Health sciences Homology Hospitals House mouse Humans Kv Channel-Interacting Proteins - genetics Laboratories Male Males Medical schools Medicine Meta-analysis Mice Pediatrics Phenotype Physicians Polymorphism, Single Nucleotide Precision medicine Public health Respiratory tract Respiratory tract diseases Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Tuberculosis Veterinary Science
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Beschreibung
Zusammenfassung:	Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with mouse AHR and human asthma-related phenotypes. Our goal was to identify asthma-related genes by integrating AHR associations in mouse with human genome-wide association study (GWAS) data. We used Efficient Mixed Model Association (EMMA) analysis to conduct a GWAS of baseline AHR measures from males and females of 31 mouse strains. Genes near or containing SNPs with EMMA p-values
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0056179