Association of TCF7L2 gene polymorphisms with T2DM in the population of Hyderabad, India

Association of TCF7L2 gene polymorphisms with T2DM in the population of Hyderabad, India

We attempt to evaluate the nature of association of TCF7L2 gene variants with T2DM, for the first time in the population of Hyderabad, which is considered to be diabetic capital of India. It is a case-control study of the three SNPs of TCF7L2, rs7903146, rs12255372 and rs11196205, genotyped on Seque...

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Veröffentlicht in:PloS one 2013-04, Vol.8 (4), p.e60212-e60212
Hauptverfasser: Uma Jyothi, Kommoju, Jayaraj, Maruda, Subburaj, Kadarkarai Samy, Prasad, Kotla Jaya, Kumuda, Irgam, Lakshmi, Velaga, Reddy, Battini Mohan
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Alleles
Biology
Body mass
Cardiovascular disease
Case-Control Studies
Development and progression
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - genetics
Diabetes therapy
Family medical history
Female
Gene expression
Gene Frequency
Genes
Genetic aspects
Genetic Predisposition to Disease - genetics
Genomes
Genotypes
Glucose
Haplotypes
Health risks
Humans
India
Laboratories
Male
Medical records
Medicine
Minority & ethnic groups
Polymorphism, Single Nucleotide
Population
Risk management
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
Transcription Factor 7-Like 2 Protein - genetics
Type 2 diabetes
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Beschreibung
Zusammenfassung:We attempt to evaluate the nature of association of TCF7L2 gene variants with T2DM, for the first time in the population of Hyderabad, which is considered to be diabetic capital of India. It is a case-control study of the three SNPs of TCF7L2, rs7903146, rs12255372 and rs11196205, genotyped on Sequenom Massarray platform, in a sample of 758 patients and 621 controls. The risk allele frequency of the three SNPs was found to be significantly higher in the T2DM cases than controls, implicating susceptibility for diabetes (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0060212