Cobalamin analogues in humans: a study on maternal and cord blood

Haptocorrin (HC) carries cobalamin analogues (CorA), but whether CorA are produced in the body is unknown. All cobalamins (Cbl) to the foetus are delivered by the Cbl-specific protein transcobalamin (TC), and therefore analysis of cord serum for CorA may help to clarify the origin of CorA. HC-CorA w...

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Veröffentlicht in:	PloS one 2013-04, Vol.8 (4), p.e61194-e61194
Hauptverfasser:	Hardlei, Tore Forsingdal, Obeid, Rima, Herrmann, Wolfgang, Nexo, Ebba
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Binding sites Biochemistry Biology Chemistry Chromatography Chromatography, High Pressure Liquid Cord blood Enzymes Female Fetal Blood - chemistry Fetus Fetuses Gestational Age High-performance liquid chromatography Humans Infant, Newborn Liquid chromatography Medicine Mothers Neonates Newborn babies Newborn infants Plasma Pregnancy - blood Proteins Radioisotopes Retention Retention time Statistical analysis Transcobalamins - analysis Vitamin B 12 - blood Vitamin B12
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Zusammenfassung:	Haptocorrin (HC) carries cobalamin analogues (CorA), but whether CorA are produced in the body is unknown. All cobalamins (Cbl) to the foetus are delivered by the Cbl-specific protein transcobalamin (TC), and therefore analysis of cord serum for CorA may help to clarify the origin of CorA. HC-CorA were quantified in paired samples of cord serum from newborns and serum from mothers (n = 69). The CorA-concentration was higher in cord serum (median = 380, range: 41-780 pmol/L) than in serum from the mothers (median = 160, range: 64-330 pmol/L), (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0061194