Aurora-A identifies early recurrence and poor prognosis and promises a potential therapeutic target in triple negative breast cancer

Triple negative breast cancer (TNBC) acquires an unfavorable prognosis, emerging as a major challenge for the treatment of breast cancer. In the present study, 122 TNBC patients were subjected to analysis of Aurora-A (Aur-A) expression and survival prognosis. We found that Aur-A high expression was...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e56919-e56919
Hauptverfasser:	Xu, Jie, Wu, Xing, Zhou, Wei-hua, Liu, An-wen, Wu, Jian-bing, Deng, Jin-yun, Yue, Cai-feng, Yang, Shao-bing, Wang, Jing, Yuan, Zhong-yu, Liu, Quentin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Apoptosis Aurora Kinases Biology Biomarkers Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Cancer research Cancer therapies Cancer treatment Cell growth Cell Line, Tumor Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Chemotherapy Enzyme Activation - drug effects Epidermal growth factor Female Gastric cancer Gene amplification Health aspects Hematology Humans Inhibition Ki-67 Antigen - metabolism Kinases Laboratories Leukemia Medical prognosis Medicine Metastasis Middle Aged Multivariate analysis Neoplasm Staging Oncology Patients Piperazines - pharmacology Prognosis Protein Kinase Inhibitors - pharmacology Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - metabolism Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Recurrence Stomach cancer Surgery Survival Survival analysis Tumors
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Zusammenfassung:	Triple negative breast cancer (TNBC) acquires an unfavorable prognosis, emerging as a major challenge for the treatment of breast cancer. In the present study, 122 TNBC patients were subjected to analysis of Aurora-A (Aur-A) expression and survival prognosis. We found that Aur-A high expression was positively associated with initial clinical stage (P = 0.025), the proliferation marker Ki-67 (P = 0.001), and the recurrence rate of TNBC patients (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0056919