Diabetes-induced hepatic pathogenic damage, inflammation, oxidative stress, and insulin resistance was exacerbated in zinc deficient mouse model

Zinc (Zn) deficiency often occurs in the patients with diabetes. Effects of Zn deficiency on diabetes-induced hepatic injury were investigated. Type 1 diabetes was induced in FVB mice with multiple low-dose streptozotocin. Hyperglycemic and age-matched control mice were treated with and without Zn c...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e49257-e49257
Hauptverfasser:	Zhang, Chi, Lu, Xuemian, Tan, Yi, Li, Bing, Miao, Xiao, Jin, Litai, Shi, Xue, Zhang, Xiang, Miao, Lining, Li, Xiaokun, Cai, Lu
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Activation AKT protein Alanine Alanine transaminase Animals Apoptosis Biology Body weight Cardiovascular disease Cell death Cell Line, Tumor Cytokinins Cytoplasm Damage accumulation Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes therapy Diet therapy Disease Models, Animal Down-Regulation Endoplasmic reticulum Ethylenediamine Ethylenediamines Fyn protein Glucose Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans Hyperglycemia - metabolism Hyperglycemia - pathology Inflammation Inflammation - metabolism Inflammation - pathology Injuries Insulin Insulin resistance Insulin Resistance - physiology Liver Liver - metabolism Liver - pathology Liver diseases Male Medicine Mice Mortality Nuclear transport Nutrient deficiency Oxidation resistance Oxidative stress Oxidative Stress - physiology Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Regulators Rodents Streptozocin Supplements Transcription Translocation Type 2 diabetes Zinc Zinc (Nutrient) Zinc - deficiency Zinc compounds
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Beschreibung
Zusammenfassung:	Zinc (Zn) deficiency often occurs in the patients with diabetes. Effects of Zn deficiency on diabetes-induced hepatic injury were investigated. Type 1 diabetes was induced in FVB mice with multiple low-dose streptozotocin. Hyperglycemic and age-matched control mice were treated with and without Zn chelator, N,N,N',N'-tetrakis (2-pyridylemethyl) ethylenediamine (TPEN), at 5 mg/kg body-weight daily for 4 months. Hepatic injury was examined by serum alanine aminotransferase (ALT) level and liver histopathological and biochemical changes. Hepatic Zn deficiency (lower than control level, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0049257