Extensive in vivo resilience of persistent Salmonella

Chronic infections caused by persistent pathogens represent an important health problem. Here, we establish a simple practical mouse Salmonella infection model for identifying bacterial maintenance functions that are essential for persistency. In this model, a substantial fraction of Salmonella surv...

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Veröffentlicht in:PloS one 2012-07, Vol.7 (7), p.e42007
Hauptverfasser: Barat, Somedutta, Steeb, Benjamin, Mazé, Alain, Bumann, Dirk
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Sprache:eng
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Zusammenfassung:Chronic infections caused by persistent pathogens represent an important health problem. Here, we establish a simple practical mouse Salmonella infection model for identifying bacterial maintenance functions that are essential for persistency. In this model, a substantial fraction of Salmonella survived even several days of treatment with a potent fluoroquinolone antibiotic indicating stringency of the model. Evaluation of twelve metabolic defects revealed dramatically different requirements for Salmonella during persistency as compared to acute infections. Disrupted synthesis of unsaturated/cyclopropane fatty acids was the only defect that resulted in rapid Salmonella clearance suggesting that this pathway might contain suitable targets for antimicrobial chemotherapy of chronic infection.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0042007