Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight

Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e48046
Hauptverfasser:	Molendijk, Marc L, Haffmans, Judith P M, Bus, Boudewijn A A, Spinhoven, Philip, Penninx, Brenda W J H, Prickaerts, Jos, Oude Voshaar, Richard C, Elzinga, Bernet M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anxiety Anxiety - blood Behavior Biology Body Mass Index Brain Brain research Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Case-Control Studies Cognition & reasoning Correlation Correlation coefficient Correlation coefficients Depression - blood Female Humans Hypotheses Male Medicine Mental depression Middle Aged Monthly variations Netherlands Primary care Psychiatry Regression Analysis Rodents Seasonal variations Seasons Social and Behavioral Sciences Studies Suicides & suicide attempts Sunlight Time Factors
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Beschreibung
Zusammenfassung:	Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands Study of Depression and Anxiety (NESDA). Analyses by month of sampling (monthly n's >196) showed pronounced seasonal variation in serum BDNF concentrations (P
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0048046