Over-expression of DSCR1 protects against post-ischemic neuronal injury

The Down syndrome candidate region 1 (DSCR1) gene is located on human chromosome 21 and its protein is over-expressed in brains of Down syndrome individuals. DSCR1 can modulate the activity of calcineurin, a phosphatase abundant in the brain, but its influence on stroke outcome is not clear. We comp...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47841-e47841
Hauptverfasser:	Brait, Vanessa H, Martin, Katherine R, Corlett, Alicia, Broughton, Brad R S, Kim, Hyun Ah, Thundyil, John, Drummond, Grant R, Arumugam, Thiruma V, Pritchard, Melanie A, Sobey, Christopher G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - genetics Biochemistry Biology Brain Brain - drug effects Brain - metabolism Brain - pathology Brain damage Brain Infarction - genetics Brain Infarction - metabolism Brain Injuries - genetics Brain Injuries - metabolism Brain research Calcineurin Cell death Cells, Cultured Cerebral blood flow Chromosome 21 Comparative analysis Cytokines - genetics Cytokines - metabolism Deprivation Down syndrome Down's syndrome Edema Edema - genetics Edema - metabolism Gene Expression Genetic engineering Genetic research Glucose Glucose - metabolism Glucose - pharmacology Grip strength Hippocampus Humans Immunoblotting Immunohistochemistry Infiltration Inflammation Inflammation Mediators - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Ischemia Ischemic Attack, Transient - genetics Ischemic Attack, Transient - metabolism Laboratory animals Lesions Leukocytes Leukocytes (neutrophilic) Male Medicine Metabolism Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Microglia Molecular biology mRNA Muscle Proteins - genetics Muscle Proteins - metabolism Neurological complications Neurons Neuropathology Neutrophil Infiltration - genetics Neutrophils Occlusion Overexpression Pharmacology Phosphatases Proteins Reperfusion Reperfusion Injury - genetics Reperfusion Injury - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Rodents Stroke Time Factors Transgenic mice Traumatic brain injury Veins & arteries
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