Blunted sodium excretion in response to a saline load in 5 year old female sheep following fetal uninephrectomy

Previously, we have shown that fetal uninephrectomy (uni-x) causes hypertension in female sheep by 2 years of age. Whilst the hypertension was not exacerbated by 5 years of age, these uni-x sheep had greater reductions in renal blood flow (RBF). To further explore these early indications of a declin...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e47528
Hauptverfasser:	Lankadeva, Yugeesh R, Singh, Reetu R, Hilliard, Lucinda M, Moritz, Karen M, Denton, Kate M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Angiotensin Angiotensins Animals Arterial Pressure Biology Blood flow Blood pressure Cardiovascular disease Congenital diseases Development and progression Endowment Excretion Female Females Fetuses Gene expression Gene Expression - drug effects Genetic aspects Glomerular filtration rate Glomerular Filtration Rate - drug effects Homeostasis Hypertension Hypertension - chemically induced Kidney diseases Males Medicine Na+/K+-exchanging ATPase Nephrectomy - adverse effects Ovis aries Physiology Psychological aspects Renal Circulation - drug effects Renal cortex Renal function Renal insufficiency Renin Risk factors Rodents Sheep Sodium Sodium - analysis Sodium Chloride - administration & dosage Sodium-Potassium-Exchanging ATPase - metabolism Surgery Veterinary Science
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Zusammenfassung:	Previously, we have shown that fetal uninephrectomy (uni-x) causes hypertension in female sheep by 2 years of age. Whilst the hypertension was not exacerbated by 5 years of age, these uni-x sheep had greater reductions in renal blood flow (RBF). To further explore these early indications of a decline in renal function, we investigated the renal response to a saline load (25 ml/kg/40 min) in 5-year old female uni-x and sham sheep. Basal mean arterial pressure was ∼15 mmHg greater (P(Group)
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0047528