Effects of renal sympathetic denervation on post-myocardial infarction cardiac remodeling in rats
To investigate the therapeutic effects of renal denervation (RD) on post- myocardial infarction (MI) cardiac remodeling in rats, the most optimal time for intervention and the sustainability of these effects. One hundred SPF male Wistar rats were randomly assigned to N group (Normal, n=10), MI group...
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| creator | Hu, Jialu Ji, Meng Niu, Conway Aini, Asiyeguli Zhou, Qina Zhang, Ling Jiang, Tao Yan, Yan Hou, Yuemei |
| description | To investigate the therapeutic effects of renal denervation (RD) on post- myocardial infarction (MI) cardiac remodeling in rats, the most optimal time for intervention and the sustainability of these effects.
One hundred SPF male Wistar rats were randomly assigned to N group (Normal, n=10), MI group(MI, n=20),RD group (RD, n=10), RD3+MI (MI three days after RD, n=20), MI1+RD (RD one day after MI, n=20), MI7+RD (RD seven days after MI, n=20). MI was produced through thoracotomic ligation of the anterior descending artery. RD was performed through laparotomic stripping of the renal arteriovenous adventitial sympathetic nerve. Left ventricular function, hemodynamics, plasma BNP, urine volume, urine sodium excretion and other indicators were measured four weeks after MI.
(1) The left ventricular function of the MI group significantly declined (EF |
| doi_str_mv | 10.1371/journal.pone.0045986 |
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One hundred SPF male Wistar rats were randomly assigned to N group (Normal, n=10), MI group(MI, n=20),RD group (RD, n=10), RD3+MI (MI three days after RD, n=20), MI1+RD (RD one day after MI, n=20), MI7+RD (RD seven days after MI, n=20). MI was produced through thoracotomic ligation of the anterior descending artery. RD was performed through laparotomic stripping of the renal arteriovenous adventitial sympathetic nerve. Left ventricular function, hemodynamics, plasma BNP, urine volume, urine sodium excretion and other indicators were measured four weeks after MI.
(1) The left ventricular function of the MI group significantly declined (EF<40%), plasma BNP was elevated, urine output was significantly reduced, and 24-hour urine sodium excretion was significantly reduced. (2) Denervation can be achieved by surgically stripping the arteriovenous adventitia, approximately 3 mm from the abdominal aorta. (3) In rats with RD3+MI, MI1+RD and MI7+RD, compared with MI rats respectively, the LVEF was significantly improved (75 ± 8.4%,69 ± 3.8%,73 ± 5.5%), hemodynamic indicators were significantly improved, plasma BNP was significantly decreased, and the urine output was significantly increased (21.3 ± 5 ml,23.8 ± 5.4 ml,25.2 ± 8.7 ml). However, the urinary sodium excretion also increased but without significant difference.
RD has preventive and therapeutic effects on post-MI cardiac remodeling.These effects can be sustained for at least four weeks, but there were no significant differences between denervation procedures performed at different times in the course of illness. Cardiac function, hemodynamics, urine volume and urine sodium excretion in normal rats were not affected by RD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0045986</identifier><identifier>PMID: 23049914</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Aorta ; Aorta, Abdominal - pathology ; Beta blockers ; Biology ; Blood pressure ; Body Weight ; Cardiology - methods ; Chronic illnesses ; Denervation ; Disease Models, Animal ; Excretion ; Heart ; Heart diseases ; Hemodynamics ; Indicators ; Kidney - innervation ; Male ; Medicine ; Models, Biological ; Myocardial infarction ; Myocardial Infarction - physiopathology ; Rats ; Rats, Wistar ; Rodents ; Sodium ; Sodium - chemistry ; Stripping ; Sustainability ; Sympathectomy ; Time Factors ; Urine ; Ventricle ; Ventricular Function, Left ; Ventricular Remodeling - physiology</subject><ispartof>PloS one, 2012-09, Vol.7 (9), p.e45986</ispartof><rights>Hu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Hu et al 2012 Hu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-25faf7a722ef15e91ec4bb66752bf3a0ee4f366bebbf44a4e2833e0e38d42bbe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458818/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458818/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23049914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chen, Xiongwen</contributor><creatorcontrib>Hu, Jialu</creatorcontrib><creatorcontrib>Ji, Meng</creatorcontrib><creatorcontrib>Niu, Conway</creatorcontrib><creatorcontrib>Aini, Asiyeguli</creatorcontrib><creatorcontrib>Zhou, Qina</creatorcontrib><creatorcontrib>Zhang, Ling</creatorcontrib><creatorcontrib>Jiang, Tao</creatorcontrib><creatorcontrib>Yan, Yan</creatorcontrib><creatorcontrib>Hou, Yuemei</creatorcontrib><title>Effects of renal sympathetic denervation on post-myocardial infarction cardiac remodeling in rats</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To investigate the therapeutic effects of renal denervation (RD) on post- myocardial infarction (MI) cardiac remodeling in rats, the most optimal time for intervention and the sustainability of these effects.
One hundred SPF male Wistar rats were randomly assigned to N group (Normal, n=10), MI group(MI, n=20),RD group (RD, n=10), RD3+MI (MI three days after RD, n=20), MI1+RD (RD one day after MI, n=20), MI7+RD (RD seven days after MI, n=20). MI was produced through thoracotomic ligation of the anterior descending artery. RD was performed through laparotomic stripping of the renal arteriovenous adventitial sympathetic nerve. Left ventricular function, hemodynamics, plasma BNP, urine volume, urine sodium excretion and other indicators were measured four weeks after MI.
(1) The left ventricular function of the MI group significantly declined (EF<40%), plasma BNP was elevated, urine output was significantly reduced, and 24-hour urine sodium excretion was significantly reduced. (2) Denervation can be achieved by surgically stripping the arteriovenous adventitia, approximately 3 mm from the abdominal aorta. (3) In rats with RD3+MI, MI1+RD and MI7+RD, compared with MI rats respectively, the LVEF was significantly improved (75 ± 8.4%,69 ± 3.8%,73 ± 5.5%), hemodynamic indicators were significantly improved, plasma BNP was significantly decreased, and the urine output was significantly increased (21.3 ± 5 ml,23.8 ± 5.4 ml,25.2 ± 8.7 ml). However, the urinary sodium excretion also increased but without significant difference.
RD has preventive and therapeutic effects on post-MI cardiac remodeling.These effects can be sustained for at least four weeks, but there were no significant differences between denervation procedures performed at different times in the course of illness. Cardiac function, hemodynamics, urine volume and urine sodium excretion in normal rats were not affected by RD.</description><subject>Animals</subject><subject>Aorta</subject><subject>Aorta, Abdominal - pathology</subject><subject>Beta blockers</subject><subject>Biology</subject><subject>Blood pressure</subject><subject>Body Weight</subject><subject>Cardiology - methods</subject><subject>Chronic illnesses</subject><subject>Denervation</subject><subject>Disease Models, Animal</subject><subject>Excretion</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Hemodynamics</subject><subject>Indicators</subject><subject>Kidney - innervation</subject><subject>Male</subject><subject>Medicine</subject><subject>Models, Biological</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Sodium</subject><subject>Sodium - chemistry</subject><subject>Stripping</subject><subject>Sustainability</subject><subject>Sympathectomy</subject><subject>Time Factors</subject><subject>Urine</subject><subject>Ventricle</subject><subject>Ventricular Function, Left</subject><subject>Ventricular Remodeling - physiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1r3DAQhkVpaNJN_kFpDb3k4q2-LV8KISRtINBLexaSPNp4sS1X0gb231fJOiEpQQKJmXcezYgXoU8ErwlryLdt2MXJDOs5TLDGmItWyXfohLSM1pJi9v7F_Rh9TGmLsWBKyg_omDLM25bwE2SuvAeXUxV8FaHwqrQfZ5PvIPeu6mCCeG9yH6aq7DmkXI_74Ezs-iLtJ2-ie8weQq4wxtDB0E-bkq2iyekUHXkzJDhbzhX6c331-_Jnffvrx83lxW3tREtzTYU3vjENpeCJgJaA49ZK2QhqPTMYgHsmpQVrPeeGA1WMAQamOk6tBbZCXw7ceQhJL7-TNGFUCkGVaIvi5qDogtnqOfajiXsdTK8fAyFutIll7AE0Fx0IRxvlXMdxY5VnjW8soYxJj9uusL4vr-3sCJ2DKUczvIK-zkz9nd6Ee824UIqoAjhfADH83UHKeuyTg2EwE4Rd6Ru3QhHGy1qhr_9J356OH1QuhpQi-OdmCNYPjnmq0g-O0YtjStnnl4M8Fz1ZhP0D-yvBqQ</recordid><startdate>20120926</startdate><enddate>20120926</enddate><creator>Hu, Jialu</creator><creator>Ji, Meng</creator><creator>Niu, Conway</creator><creator>Aini, Asiyeguli</creator><creator>Zhou, Qina</creator><creator>Zhang, Ling</creator><creator>Jiang, Tao</creator><creator>Yan, Yan</creator><creator>Hou, Yuemei</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120926</creationdate><title>Effects of renal sympathetic denervation on post-myocardial infarction cardiac remodeling in rats</title><author>Hu, Jialu ; Ji, Meng ; Niu, Conway ; Aini, Asiyeguli ; Zhou, Qina ; Zhang, Ling ; Jiang, Tao ; Yan, Yan ; Hou, Yuemei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-25faf7a722ef15e91ec4bb66752bf3a0ee4f366bebbf44a4e2833e0e38d42bbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Aorta, Abdominal - pathology</topic><topic>Beta blockers</topic><topic>Biology</topic><topic>Blood pressure</topic><topic>Body Weight</topic><topic>Cardiology - methods</topic><topic>Chronic illnesses</topic><topic>Denervation</topic><topic>Disease Models, Animal</topic><topic>Excretion</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Hemodynamics</topic><topic>Indicators</topic><topic>Kidney - innervation</topic><topic>Male</topic><topic>Medicine</topic><topic>Models, Biological</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Sodium</topic><topic>Sodium - chemistry</topic><topic>Stripping</topic><topic>Sustainability</topic><topic>Sympathectomy</topic><topic>Time Factors</topic><topic>Urine</topic><topic>Ventricle</topic><topic>Ventricular Function, Left</topic><topic>Ventricular Remodeling - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Jialu</creatorcontrib><creatorcontrib>Ji, Meng</creatorcontrib><creatorcontrib>Niu, Conway</creatorcontrib><creatorcontrib>Aini, Asiyeguli</creatorcontrib><creatorcontrib>Zhou, Qina</creatorcontrib><creatorcontrib>Zhang, Ling</creatorcontrib><creatorcontrib>Jiang, Tao</creatorcontrib><creatorcontrib>Yan, Yan</creatorcontrib><creatorcontrib>Hou, Yuemei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Jialu</au><au>Ji, Meng</au><au>Niu, Conway</au><au>Aini, Asiyeguli</au><au>Zhou, Qina</au><au>Zhang, Ling</au><au>Jiang, Tao</au><au>Yan, Yan</au><au>Hou, Yuemei</au><au>Chen, Xiongwen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of renal sympathetic denervation on post-myocardial infarction cardiac remodeling in rats</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-09-26</date><risdate>2012</risdate><volume>7</volume><issue>9</issue><spage>e45986</spage><pages>e45986-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To investigate the therapeutic effects of renal denervation (RD) on post- myocardial infarction (MI) cardiac remodeling in rats, the most optimal time for intervention and the sustainability of these effects.
One hundred SPF male Wistar rats were randomly assigned to N group (Normal, n=10), MI group(MI, n=20),RD group (RD, n=10), RD3+MI (MI three days after RD, n=20), MI1+RD (RD one day after MI, n=20), MI7+RD (RD seven days after MI, n=20). MI was produced through thoracotomic ligation of the anterior descending artery. RD was performed through laparotomic stripping of the renal arteriovenous adventitial sympathetic nerve. Left ventricular function, hemodynamics, plasma BNP, urine volume, urine sodium excretion and other indicators were measured four weeks after MI.
(1) The left ventricular function of the MI group significantly declined (EF<40%), plasma BNP was elevated, urine output was significantly reduced, and 24-hour urine sodium excretion was significantly reduced. (2) Denervation can be achieved by surgically stripping the arteriovenous adventitia, approximately 3 mm from the abdominal aorta. (3) In rats with RD3+MI, MI1+RD and MI7+RD, compared with MI rats respectively, the LVEF was significantly improved (75 ± 8.4%,69 ± 3.8%,73 ± 5.5%), hemodynamic indicators were significantly improved, plasma BNP was significantly decreased, and the urine output was significantly increased (21.3 ± 5 ml,23.8 ± 5.4 ml,25.2 ± 8.7 ml). However, the urinary sodium excretion also increased but without significant difference.
RD has preventive and therapeutic effects on post-MI cardiac remodeling.These effects can be sustained for at least four weeks, but there were no significant differences between denervation procedures performed at different times in the course of illness. Cardiac function, hemodynamics, urine volume and urine sodium excretion in normal rats were not affected by RD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23049914</pmid><doi>10.1371/journal.pone.0045986</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Aorta Aorta, Abdominal - pathology Beta blockers Biology Blood pressure Body Weight Cardiology - methods Chronic illnesses Denervation Disease Models, Animal Excretion Heart Heart diseases Hemodynamics Indicators Kidney - innervation Male Medicine Models, Biological Myocardial infarction Myocardial Infarction - physiopathology Rats Rats, Wistar Rodents Sodium Sodium - chemistry Stripping Sustainability Sympathectomy Time Factors Urine Ventricle Ventricular Function, Left Ventricular Remodeling - physiology |
| title | Effects of renal sympathetic denervation on post-myocardial infarction cardiac remodeling in rats |
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